Has anyone been on TMZ over a year?

My wife was on TMZ for a year at full dose, then continued but went down to lower dose at 6 week intervals rather than 4. Her bloods have always been (just about) OK, though white blood count has got very low. No other side effects.

Then after 4 (I think) rounds of reduced dose she had a recurrence and moved onto lomustine. tbh I'm dubious about the benefits of more than 1 year of TMZ - and the trial evidence seems to be there's no advantage over 6 months. My worry is that my wife's immune system is now less able to respond to immunotherapy as a result of the long chemo, if that's what we need to move on to. But what do I know...? Maybe the extended TMZ has delayed the recurrence. Certainly she has luckily had a good quality of life with few side effects and deficits. Good luck

Thank you HW66,

That's useful to know -yes it's hard to know what to go onto for the best, everyone's experience is so different.At the moment he is fairing well physically.

I'll see what his next MRI brings.