Bendamustine and rituximab Vs R-chop

I had a different treatment journey (R-EPOCH) but did have Rituximab as part of my treatment and it was very effective.

You can search R‐B v R‐CHOP using the search tool and see any hits.

Lets see if any folks who had R-B as their first line treatment are looking in.

Hello Thehighlander, 

I am not really finding any details. All I find is relapsed/refractory treatment. But he was never treated before. 

My dad doesn't have any symptoms and I am very frightened that we are not having the right things done. 

He has a tonsils neoplasms and several lymph nodes enlarged in the neck, axillary and in ingvinal. No temperature, no weight loss. It all started with this enlarged lymph in the neck. 

I expected to be offered R-chop, but now I am a bit surprised. They say it's less toxic and want to start with it. 

The post below is about this very subject but for FLHL

https://community.macmillan.org.uk/cancer_types/follicular_lymphoma/f/dcfa614e-f230-4246-b297-7703194fcf7f/190705/r-b-vs-r-chop

The main thing we learnt over the years is that these Consultants do know what is best especially looking at how the NHL is presenting and on the whole NHL is NHL.

Yes, I have read that R-B is less toxic and often used as first line treatment for some types of NHL.

Hi your right that r-chop is the standard treatment for dlbc lymphoma and has been proven to be effective in many people especially since the R was added to CHOP. B&R is mainly used for FNHL and whilst its not been seen as a standard treatment I have over the last month or so seen a paper about B & R or B & O the later a second generation version that does not have the issues associated with R (rituximab)

Unfortunately I cannot find the paper to share, but do remember outcomes were similar, so what your dad needs to do is discuss with his doctor why this treatment other than being less toxic and is it proven to be as effective as rchop and does he have a choice.

sorry cannot be more helpful

John  

ps id he being treated in the UK?

Thank you John! We will see how it goes. 

I would get a second opinion. I have read a report about a study of this for very frail elderly people, not for anyone else. I would definitely want an explanation and wouldn't just leave it.

Hello Londoner12, 

We started with this. My dad is young but he had a brain stroke several months ago. Maybe that's why. They said he can be moved to the rchop in the next therapies depending on the outcomes. I read that this therapy is a bit more easier to take from the patient. Still concerned but I try to believe the doctor knows better. 

Hope it works for us

Ah well that makes more sense. If his body couldn't cope with RCHOP they are doing the next best thing and it sounds like they know what they are doing. Here's hoping for a really good response.