Mutated Disease

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Hey everyone,

I hope that everyone is as well as can be. My wife has been suffering with secondary breast cancer from just over 2 years now, she has been through many lines of treatment which have unfortunately not worked for her.

She is currently on capeciterbine which was the last line of treatment, we had an appointment today to discuss a recent biopsy on an enlarged lymph node in her neck and to get results from a recent scan.

Unfortunately the scan result were bad, progression in lungs, liver and 2 new areas so the treatment has now been stopped. They did say that the biopsy results showed that the type of cancer she has hormone positive had mutated to triple negative.

has anyone had any experience with their cancer mutating to a different type? Are there alternative treatments for this cancer type that have not been explored, this would explain the other treatments not working.

we are a bit lost now, back in the land of the unknown!

any advice would be appreciated

Warm regards 

Mc 

  • I am sorry to hear of your wife’s situation. I don’t have experience of cancer mutating, but I do have metastatic TNBC. mTNBC is usually tested to see whether it expresses PD-L1, and if so it can be treated with Pembrolizumab along with chemo. It is used as first line for suitable TNBC and I am unsure whether having had so many lines (albeit for hormone positive cancer) would rule it out. Worth asking though. 

  • Hey Coddfish,

    Thank you for taking the time to reply, we are waiting for the doctors to have an MDT meeting this week to see the status, she has already had prembo as part of a clinical trial she was involved in recently.. so I guess that ones not a possibility, We will see after their meeting I guess… having slept on it I’m now very worried.

    warm regards 

    michael