Phesgo, Kadcyla and Enhertu stopped working

Hi Judith. I’m so sorry about your situation. I know the terror of progression.

Have you had the liquid biopsy test? It’s available privately. Mine was done through Roche and funded by BUPA. I know it might not be possible for everyone and I don’t want to be insensitive but it has been a literal lifeline for me.

I kept progressing on hormone treatments and then on capecitabine. I was looking down the barrel of IV chemo only.
The test found  that my previous HER2 neg had become HER2 low and also found germline BRCA gene. This was a game changer as there is no known family history of this type of cancer. It’s opened up new treatments for me.   I wish you luck. Please try to stay positive. Drugs are being developed all the time and there might be something around the corner for you. 
Karen 

Thank you for answering. Can I just ask is a liquid biopsy different from the one offered on the NHS?

i don’t have private health insurance but would be interested in finding out more about it and of course the cost.

thank you though, it might give me choices 

hope you are doing well now 

Judith 

Hi Judith. I’m in Scotland and I know liquid biopsy tests are not on NHS. Look at Roche website. It’s a blood test which examines circulating DNA. Your oncologist will know about it. These tests are becoming standard in the US now. Good luck. 
Karen 

Thank you so much for your replies, they gave me hope while I waited for results. My biopsy also showed that the cancer had changed from Her2  positive to HER2 negative which was why all Herceptin based treatments had stopped working. So change of treatment and hopefully an improvement in outcomes.