Ribociclib Side Effects

I’ve been on Ribociclib and Letrozole for 2.5 years and apart some nighttime hot flushes and the occasional afternoon nap I’m going well.  However, it didn’t start that way!  Are you on the 600mg dose?  That did not agree with me at all but the main problem  was low neutrophils.  My dose was reduced to 400mg…..still not good so for past 2 years I’ve been on 200mg and that suits me.  Getting the dose that suits you is the answer.  Your next blood test will tell your oncologist how you are coping.  Best wishes.

Hiya

thank you so much for your reply

so - I’m actually now in hospital as the diarrhoea is terrible and high temperature. Just waiting to find out what’s going on ! 
yeah I’m on 600mg of Ribociclib, it’s certainly starting to look like I am also unable to tolerate the high dose, it’s good to know that the dose can be reduced as I can’t cope with these symptoms for the long haul. 
it’s encouraging to know that you have responded so well too - sending you continued best wishes x

Sorry to hear you are in hospital……diarrhoea too!  These drugs that help us have various side effects…I’ve not had that one.  Apart from low neutrophils ((white blood cells) which can stop or delay the next  Ribociclib cycle, my worst side effect was my taste buds went haywire and everything tasted awful…..I was really miserable.  Life now is as normal as it can be, we just plan our life around medical appointments.  You will get there too.  My oncologist assured me that the 200mg dose is effective and my bloods and scans have been good ….next scan is tomorrow.

Hope you feel much better soon. X