Ribociclib side effects

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Hello everyone 

I was diagnosed with secondary breast cancer which has spread to spine a year ago I did have spinal surgery as a vertebrae was crumbling and unstable.. My Ct scans three monthly and bloods monthly  show cancer is stable and low grade so that's a positive. I started my ribocicilib in November last year had 6 rounds however I had lots of chest infections and numerous antibiotics all through this and now my lungs show inflammation caused I guess by the meds. They gave me a three  month break off tablets to help my lungs which helped. However during my 6 cycle I started to get bad gastritis and abdominal pain. It cleared up during the three months off ribo but as soon as I have gone back on them within three days it has returned and I am trying to persevere with the tablets even at a reduced dose of 400 daily. Can I ask if any of you lovely people have similar problems with ribo ? Causing indigestion IBS and gastritis ? I am worrying now it has spread to my stomach or bowel even though my latest scan a month a go shows everything stable. Xx

  • I have been on and off Ribociclib since May due to  them affecting my lungs and then having low immune system, l am now taking 2 tablets instead of 3 a day won't know if all is ok until l have another blood test next week. I have been suffering with hot flushes, nausea, and sometimes tummy problems and tiredness. 

    Hope you feel better very soon.

  • Hi Curlyp

    Thanks for your reply and hope you are doing ok. I am sorry to hear about your lung problems too. Fingers crossed your bloods are ok. X

  • I have been on Kisqali since January, I take medication for GERD which I have doubled to help with any stomach issues. Have you been given anything for your stomach problems?

  • I already take Esomeprazole 40mgs have been on it before I started ribociclib for many years. I've had irritable bowel in the past too and I just feel everything is just kicking off again. I know that stress plays a big part in all of this too xx

  • No, as the problem has only just started this week but l have injections on Friday so will mention it then. 

  • Hello,

    I'm sorry to hear about the struggles you're facing, but it's great to hear your cancer is stable—that's definitely a positive! I’ve been on Kisqali (Ribociclib) for a while now, and I can relate to some of the side effects you've mentioned. First of all, it is extremely important to use only high-quality Kisqali (Ribociclib) from reliable pharmacies, for the best treatment results and minimizing side effectsI also experienced digestive issues, including gastritis and severe indigestion, especially when I first started taking it. It seems like Ribociclib can irritate the stomach lining for some of us.

    One thing that helped me was switching to a more balanced diet and taking my meds after meals, which reduced the intensity of those stomach issues. I also talked to my doctor about it, and they suggested a proton pump inhibitor (PPI) like omeprazole to protect my stomach, which made a big difference. Maybe that’s something you could discuss with your medical team?

    As for your concerns about it spreading to your stomach or bowel, it’s totally understandable to worry, but since your scans show stability, that’s a good sign. It could very well just be the medication causing these issues rather than progression of the disease. But, of course, it's always good to bring these concerns up with your doctor, especially if the pain is persistent.

    You’re doing great persevering with the medication, but don’t hesitate to talk to your team about adjusting your treatment or managing the side effects better—your comfort is important too!

    Sending you lots of strength!