Ribociclib + Fatigue

Hi there

I have bone mets in spine, sternum and femur and was given ribociclib for 6 cycles last year but had to stop as my liver enzymes went a bit berserk. Now I’m taking similar drug palbociclib and so far no dodgy liver issues. I was worried about the side effects too. I did feel a bit woozy at first with fatigue but then it seemed to settle down. I think drinking plenty of water, fluids upto 3 litres a day has really helped with the side effects. Also, constipation cleared with more water intake. My breast care nurse told me about the fluid intake.

 best thing is that 2 years on I’m no worse and my cancer markers have halved to 58. 
good luck with your treatment xx

I keep a record printout of my bloods as it then makes sense of how your body is feeling. Good luck x

Yes!!! 3litres of water!  Really helps but you’re always dashing for a loo! 
Lots of water for your system. X

Hello. Yes this did happen to me. Unfortunately I didn’t suit Ribo. It felt like a cross between a punch to the back and a tight elastic band around the middle). I never went back on to Ribo but instead was switched to Abemaciclib (side affects diarrhoea, nausea and increasing tiredness). Hope you’re back on the path now. Take care x

Hi Starflower,

Your news that you are 2 years on really gives me hope. I have mets in my spine that broke my back and completely took me by surprise. After op I'm now just starting on Ribociclib with Exemestan and Denosumab injections as well. What I noticed is that I feel thirsty all the time and my mouth is so dry. Is this one of the side effects? I drink lots of tea - not black but fruit, yogi or ginger teas. At least 2 litres. 

Hope you continue to do well with your treatment.

Hugs, Ulla xx

Hi Ulla

yes I do get a dry mouth but since guzzling lots of water plus black tea and a coffee a day it’s improving. I do take 30 mg codeine for lower back pain  as I also have rheumatoid arthritis especially in one of my knees. 

 I’m pleased to hear your surgery is done with and you are on the treatment to help keep things at bay. Let’s keep going and beat the so called statistics! Xx

Hello!

I’ve been on Letrozole myself, and while the beginning can feel a bit challenging with side effects, I can assure you that, for many, things tend to improve over time. First of all, it is extremely important to use only high-quality Letrozole from reliable pharmacies, for the best treatment results and minimizing side effects. I had my own struggles with fatigue and lightheadedness in the early weeks, but after a while, my body seemed to adjust, and those side effects became much more manageable. It’s great to hear your side effects are mild so far – that’s a positive sign!

In my experience, the initial fatigue and wooziness can be the body getting used to the new medications. I found that staying hydrated, getting enough rest, and taking short walks when possible really helped boost my energy. It’s all about finding your rhythm. I truly hope that as your journey continues, your side effects will ease, and you’ll find ways to balance it with your day-to-day life. Hang in there – you’re doing great!