Letrozole 2 years on

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I have been on Letrozole for 21/2 years now and initially the side effects were not too bad just a bit of joint pain which went away, the tiredness and of course the constant night waking. However in the last 6 months I have suffered with severe constipation (now got laxatives) vaginal atrophy (moisturisers) and more recently repeated UTIs which my GP has said caused by low oestrogen (awaiting kidney and bladder scan) The last straw (which I’m assuming also due to Letrozole) is the indigestion, burning and belching. Life is becoming miserable oh and also coupled with Letrozole shortages to contend with. Have contacted BCN asking for a change and been told ask GP for another brand then get back in touch if it doesn’t help and she will try and reach the surgeon? Since taking myself off it 3 weeks ago (as I couldn’t get hold of any) the atrophy has eased constipation gone and sleep much better. I’m starting to think I just won’t bother any more.

Is it just me?

  • Hi  it is really interesting you say this as I am also 2 years into letrozole and have been coping really well, but have had a few (short lived) UTI symptoms in the last few weeks and I did wonder if that could be letrozole related, even after this amount of time.  Also, I have been on daily Omeprazole since chemo and that helps a lot with heartburn and indigestion.  Hope you get sorted soon, best wishes

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  • Thank you for this, I hadn’t realised the UTIs were related to the Letrozole too. The normal treatment is an oestrogen supplement! But die us that’s not possible so maybe a low dose antibiotic for a longer period was suggested once the scan results are in. Thanks for the tip about OmepraIke will try and get in at the GPS ri get that sorted 

  • It's so frustrating isn't it, something solves one problem and then causes another!  Best of luck 

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  • I’ve been out on Lansaprozole for possible hiatus hernia/gastric reflux. Starting to feelalmost human again! Thanks for your help x