Abmeciclib

I have joint pain but I think this is the Letrozole I started taking before the Abemaciclib as I was already achey - Abemaciclib has added stomach cramps and more tiredness for me but I think the joint pain is about the same though I have noticed I’ve got more pain in parts of me where I’d previously had surgery - the same happened with chemo - I assumed it was something ti do with residual inflammation.  Sorry to hear you are suffering. 

Sorry to hear you have joint pain.  If you are also on Letrozole it could be that maybe. 
I’ve had every side effect going on Amebaciclib but not bone pain.Today I have been taken off it for 3 weeks.   If I recover by then they will restart on 50mg.  I was going n 150mg. I was unlucky to be so poorly.  I don’t want to put anyone off as not everyone reacts as I did.   Most tolerate it ok. 
hope your bone pain goes away soon, sending best wishes. X

Hi Mibby, it's hard isn't it , hope you will be ok if go on 50mg the way I'm going I think I will be put on 50mg this is my third try on it blood result tomorrow so see how it is huh 

Hi Mere, yes it’s so tough I really wanted to get on with Amebaciclib but I fear it won’t be for me.  I will try the lowest dose and hope for the best.  Call it back luck but I’ve now got that dreadful cold virus with a dreadful cough. Oh to feel well again!   Best wishes to you. Xx

Yes bad hip pain and my neutrophils were low today but they have increased my dose from 100 to 150 from Monday im dreading it.

I hope you do well on the increase.  Although I’m surprised you are being increased at a time when your  neutrophils are lower.  Perhaps not too low to be concerned.  Good luck xx

Hi,

I started Abemaciclib today! After 7 hours I suffered extreme joint aches/pains, severe tiredness and 1 episode of diarrhea. Paracetamol and sleeping helped. I then took 2nd pill and within 2 hours felt he aches/pain again, along with 1 episode of diarrhea. 

Kind of scared to carry on but part of me wants to, in the hope my body adjusts to it. Early days!

Anyone suffer similar and it then eased?

Thanks xx

Yes really bad aches this week ..week 4 and skin rashes felt like death.

Told my oncology nurses but didn't seem to bother and increased my dose from 100g to 150g which I'm not prepared to take.

Hi AJM I don’t blame you . Unfortunately my body wouldn’t take this medicine. My oncologist even reduced my dose to 50mg but still felt unwell. I know the majority of people can take it thank goodness. But I couldn’t carry on . I only telling you this so you don’t feel like you are the only one . Hopefully your body will get used to the medication. Sending hugs xxx

Just phoned the helpline and they told me to come off it til they can do a review.

Why didn't they say this yesterday when I rang up the hospital im not impressed after all last year being on IV Chemo and having shingles and Sepsis.

Best wishes 

AJ