I've completed my surgery and radiotherapy and on my second month of Letrozole. My partner has been amazing, we've only been together fo a two and a half years, he's been with me every step, been to every appoinment, made me laugh, been then when I'm scared, kept me busy and supported me in every way.
So why I have I turned into a bad tempered, snappy old shrew with him? I'm irritatable, snappy and moody, which honestly isn't like me. I'm normally a pretty laid back fun person. I have recognised it's me who has changed which I guess is a good start, apologised and as always he's really understanding. Has anyone else found change of mood after their treatment. I more like a my old teenage self with PMT complete with strops than the mature happy great humoured person I was.
Hi,
It could be the Letrozole that is making you irritable. I'm on the Femara which is the same, only not the generic and I'm irritable, I know they're the cause but obviously need to take them.
Sorry to hear you are going through it too. I'm lucky that I've recognised it is me and apologised/explained to my partner who has been really understanding. I can't carry on like this, I am way too old for teenage mood swings. I guesss I'll have to keep a close eye on it and get help if it gets worse.
Hi,
Go back to your oncologist and ask to try another aromatase inhibitor eg exemestane or even a different brand of letrozole, If you haven't had the brand named Letrozole Femara start with that. Brand names are more expensive so is often avoided. I am currently on Aromasin the brand name for exemestane and I think it has made me less moody than when I was on one of the non-brand varieties.
Good luck with it. I admit I find this post part of the treatment the most difficult because you think you should be happy at recovery and be back to normal. It's especially depressing when you consider you have 5-10 years of it.
Whatever cancer throws your way, we’re right there with you.
We’re here to provide physical, financial and emotional support.
© Macmillan Cancer Support 2025 © Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Also operating in Northern Ireland. A company limited by guarantee, registered in England and Wales company number 2400969. Isle of Man company number 4694F. Registered office: 3rd Floor, Bronze Building, The Forge, 105 Sumner Street, London, SE1 9HZ. VAT no: 668265007