denosumab and broken tooth- what are the risks

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Dear Group, 

I am having difficulties as the denosumab has been delayed and this is due to my teeth  not having been checked properly for the all clear. I have stage 4 cancer and am feeling very sick. I am getting weaker and thinner and more fatigued. 

As I am in a bit of a rush, what happens if the denosumab is given and the teeth are checked later on. I have been told there is no infection with the tooth but I was also informed that it would be more sensible to have it checked out again and have any operations such as a crown if that is what needed to happen. Can I have a crown after the denosumab as my cancer spreading is my biggest worry. What do you think?

Eli 

  • I think they like you to have all dental work done prior to chemo because of the risk of infection. If you have a broken tooth and then your immune system is compromised with chemo, then you might get a severe infection that will leave you hospitalised. 

    I was able to get dental appointments very quickly when they knew my situation and was always put to top of the queue. 

    I realised just how much my immune system is still affected by chemo 7 months on recently when I got a tooth infection - I've never had one before. My dentist said it's because my immune system is still all over the place. It was pretty severe, I would not have liked to have had that during chemo.

  • Hi Eli

    I just had a look on the NICE Guideline web site https://bnf.nice.org.uk/drug/denosumab.html  

    It says

    1. A dental examination and appropriate preventative dentistry before starting treatment are now recommended for all patients
    2. Do not start denosumab in patients with a dental or jaw condition requiring surgery, or in patients who have unhealed lesions from dental or oral surgery

    The medics will not likely go against this as NICE Guidelinea are considered to be best evidence-based practice.

    I think you need to be trying to get the broken tooth attended to as soon as possible. Some cancer hospitals have links to either the Public Dental Service or Oral Surgery Departments who can sometimes help out if it is difficult to get care through the general dental services. First port of call would be your own dentist.

    Good luck getting this treated.

    WallyDug