Exacerbation of Peripheral Neuropathy while on Exemestane

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Hello I am HER2+ and ER+ IDC diagnosed 14/8/23. I had to stop all chemotherapy in May with another 8 treatments to go due to chemo induced Peripheral Neuropathy ( grade 3) It had reduced to a grade 1 until a couple of weeks ago around the time I started Exemestane an aromatase inhibitor. I’m back to grade 3 which is frustrating and worrying. I’ve already been taken off Letrazole to go onto Exemestane. I am on Exemestane for 7-10 years 

Has anyone else found the aromatase inhibitors made their PN worse? I know it can cause Carpel Tunnel but this is in my hands and feet . Awake with the pain and discomfort . 
Thanks 

  • Hi , I was diagnosed the same time last year and had the cancer removed I was lucky it hadn’t spread a had a 5 day course of radiotherapy and the infusion for my bones twice a year for the  next 3 yrs I’m on letrozol for 10 yrs and I’m 75, found a few aches and pains at the start of letrozole but from other users they suggested staying active so I walk the dogs and do a senior  excercise class and started Tia  chi which I love and  most of my pain I now just put down to my age .which is bearable  worth a try .. good luck 

  • Thanks for the reply…in addition to the issues with breast cancer , in 2023 i was diagnosed with colon cancer that required removal of part of my large intestines.  After discussion with colon oncologist about chemo, he advised NOT to have it as i had been through the trenches already….IF I hadn’t had such a rough time with the breast meds i would still be taking them, but just feel life is returning to some sort of normalcy for me without them.  I DO wish all the best for each of us juggling the do’s or don’ts of radiation, chemo and the toxic medication treatment. 

  • Oh goodness, I’m so sorry that you’ve had another cancer , that must be tough. How are you doing ? Quality of life is so important. 
    I had a bizarre 5 min phone appt today with an interim oncologist as mine has left. It was for the results f a CT scan to check for bone mets. It was clear that this chap hadn’t read the report and I had to ask for the results . It seems there are changes in my spine which indicate cancer. He was very casual and matter of fact about it. He wasn’t sure what would happen next ! I’ve spoken to a Macmillan nurse and she is going to see if there’s a plan. I’m hoping the changes are non cancerous no idea how likely that is. I’m guessing I will need a PET scan to confirm diagnosis . It’s good to be able to offload on here. Thank you 

  • Im doing ok…many things about how my body functions are now different then before i had my first surgery…im sorry your now in a holding pattern, yet again, regarding what looks like an issue seen on a CT scan.  I also had a recent CT that looked as if i had a growth on my liver..but once additional tests and an MRI was performed it proved to be nothing.  When i asked about the CT, I was told CT’s are NOT as clear as MRI’s so perhaps it will be the same for you…keep the faith…

    i hope you have family around to support you moving forward.  It sure has helped me!