Letrozole - how can I help my already clicking knees?

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Hi there,

I have been taking letrozole for two weeks - bilateral thearputic mammoplastomy in November, one lymph node affected but low onco score. Radiotherapy for 15 days, and letrozole for 10 years -  and already my knees grind when I bend. I’m getting hot, not flushes really, but my body odour has changed. and my god stink by the end of the day! I am really thirsty and my skin is drinking the moisturiser despite me drinking 2 litres of water a day, it’s like I can’t quench my thirst if that makes sense?

My sleep isn’t great, but think that’s down to the anxiety, and I’m taking the tablets before bed as I had awful brain fog if I took them in the morning. I was taking HRT before because I just couldn’t function at work and I’m so stressed that it will happen now Im taking letrozole. I have to work, I have a responsible job so need to be on the ball honestly I couldn’t string a sentence together at the weekend, forgetting what I went to the shoo for that kind of thing.

Does anyone have any suggestions to combat this brain thing? Also creaking joints, I take lots of supplements anyway but am upping cod liver oil and vitamin D, but I can’t believe that after just two weeks it’s causing so much difference - it’s like a creaky door when I bend my knee so I’m worried about damage, I’m not sure if I can take collagens anymore for my skin and aren’t sure what to replace them with to stop skin drying out  so much.

I know that I’m so lucky i’m so many ways, the cancer was multi focial and  bigger than any scan showed, ER and PR positive so I have to do everything I can to stop anything, and want to do all I can to have the best quality of life being as healthy as I can - any tips appreciated xxxxxx 

  • Hi, sorry to hear you're struggling and worried about letrozole.  I've been in it for about 18 months. My brain fog isn't awful, though I do forget words, but my memory is a challenge. I also work so I basically take notes in every meeting or call and use them to refer back to. I take them electronically so it's not that I have to carry lots of notebooks around.

    regarding the joint pain, I find that when I manage to walk around 10,000 steps per day there's a noticeable difference and it's so much better than the days I do not manage to exercise.  This is a direct correlation that I've observed a lot, though trying to fit in time to walk, especially in winter, is a challenge.

    hope this helps, best wishes 

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  • That really does thanks so much IrishGirl16, I hate to moan and know that it could be so much worse.   You think that once the treatment is almost over that’s it don’t you, I’m definitely going to up the walking xxxx Take care 

  • I'm going to be on Letrozole after whatever comes next. Already got painful knees. I like to be prepared. Good to know walking helps. Does it have to be walking at speed or can it include walking around shops as well. Some days are much slower than others. I'm 66 so already well past menopause. Such fun. X

  • Hi, absolutely agree, I thought what chemo, surgery and radiotherapy were done I would be back to normal. But this really is the gift that keeps on giving and every good treatment seems to cause another issue. I must admit though, I am lucky and don't suffer  too many side effects.  Best of luck 

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  • Hi, I am not a speed walker, for me it's the movement that helps and I don't do long hikes, more like 30-45 minutes a couple of times a day.  Best of luck 

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  • Sorry to hear you're struggling. I've been on Letrozole for about 15 months now. Initially the side effects knocked me for six - the worst was the night sweats which meant I wasn't sleeping and could barely function. My consultant prescribed Venlafaxine, which has counteracted the night sweats which was a great relief. I'm also suffering brain fog/memory issues. I sometimes start a sentence and then my brain seems to glitch and I have no idea of the word I need or the point I was making. If I'm at work I take notes and if I want to make a comment but can't straightaway I make notes/a mindmap of my thought processes. I also come out with very random words - eg getting the radiator out to mow the lawn! I'm about to call the BCN to discuss my aches and pains. My hands are affected the worst - some days are better/worse than others. On bad days my fingers don't work properly (eg holding a pen, touch typing) and can get stuck (trigger finger?). On good days I can still cross my fingers and open a screw top bottle of wine (yay!). I've noticed my knees and ankles cracking more. As Irishgirl16 says, I find my knees are worse on the days when I've moved less - even if I'm sat the desk I try to go up and down stairs a few more times than strictly necessary. I also find whether the knee pain is attributable to the Letrozole, being overweight, and/or general age-related wear and tear. I'm trying to find ways to minimise the pain/discomfort and focus on what is hopefully the positive impact of taking Letrozole.