I was diagnosed with Stage 2 grade 3 ER + breast cancer last October. I underwent single mastectomy and full lymph node removal last October. I began Chemo in February 25 followed by Radiotherapy in June/July 25. Letrozole started & 2 months ago I had round one of Abemaciclib.
I started having breathing difficulties & felt really unwell after the first week of being on Abemaciclib. My oncologist took me off the Abemaciclib after 3 weeks and I had a CT scan which showed 'interval development of an atypical ground glass abnormality in the right apex'. A previous CT, after Radiotherapy, was clear. I've since had 4 weeks of steroids, one week of antibiotics and I am still no better. While I feel better in myself I have difficulty breathing doing anything and become exhausted. I wake tired and nod off at anytime when I'm sat. Additional symptoms are a headache, pain in chest when eating, some indegestion, dizziness and shaking.
I've seen my oncologist today and unfortunately my latest CT results were not available but she has said she'll do further blood tests and refer me to a respiratory specialist.
I am also Asthmatic but my GG's asthma nurse has said it's not my asthma so my inhaler will only help to alleviate some symptoms. Despite this I have now been put on the higher 200mg Fostair inhaler and need ro use my Ventolin at times. Up until being diagnosed my asthma was well controlled.
Has anyone else experienced this?
Hi, as a fellow asthmatic who is also on Abemaciclib for over a year now, I can say my asthma has been less well managed this autumn and early winter. I’m normally fine on my Fostair (6micrograms per actuation) used 4 times a day. I found after I’d had bad sinusitis in the late summer, I needed more. I asked for a ventolin inhaler as an extra, had to push my cause and now have it on repeats. I’m also not sure quite why. Peak flow readings are a wee bit down and I’m finding I need ventolin about once a day as an extra. I know I can increase the Fostair but would rather speak to my asthma specialist nurse (however, access to one isn’t easy!)
I take Famotidine for indigestion but don’t really have any of your other symptoms. I’m wondering if I should scour the Abemaciclib literature again?
Hugs xxx
Moomy
Ps, I’m on Exemestane, my only other problems are the inevitable joint pains, worst being ankles and feet plus nightly cramps for which I eventually got prescribed quinine, that helps as cramps now wait till a relatively ‘normal’ waking time and my morning stretch before they get me!
I’m on the lowest dose of Abemaciclib and just read that yes, it can cause similar problems to worsening asthma. Hmmmm, might be worth a talk to Onco?
Hugs xxx
Moomy
Thanks Moony, my onco has said it doesn't look like drug induced pnemonotis. She's a bit baffled that I'm still struggling despite coming off the Abemaciclib for over a month now. My peak flow is still really good as is my oxygen saturation. I just get breathless
Sounds like you have a tough time with side effects.
Hugs back xx
I think I’ve caught daughters cold anyway, which might explain why I’m rough at present. She struggles this time of year anyway. She caught this one around 4-6 weeks back but hasn’t managed to throw it off, and I suspect even though we have both tried to be careful the inevitable has happened. She’s ‘living’ here at present.
Hugs xxx
Moomy
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