Tamoxifen to Exemetane to Letrozole

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Hello Everyone

I was diagnosed with Breast Cancer HER 2 Positive in 2020 had was on Tamoxifen, I was just post menopausal but as I work full time and on time own asked for Tamoxifen as was worried about joint paint with Letrozole.  I found one brand of Taxmoxifen suited me well and stayed on it for 4 years.  I then started worrying and maybe that I should transfer to Letrozole.  I was prescribed Exemestane as there are more options of lactose free, I have been on this for 6 months with a different brand each month, joint pain and tingling in fingers was awful plus joints really puffed up and I couldn't wear any rings plus put weight on around my middle.  I guess due to the steroid in it.  Its mainly my hands that suffer but I really recommend spraying magnesium on at night as it does ease it.

  As I want to give everything to this and not return I am going to try Letrozole, I am staying positive about it.  Has anyone else moved from one drug to the other? I seem to have had varied advice as to whether I have 2 weeks off before starting the new drug or can carry on - would be interested to hear anyones thoughts on this please?

Keep staying strong.

  • Hi. I went from Letrozole to Exemestane after 9 months as I found the side effects from Letrozole were awful - fatigue, joint pain, low mood, flushes. I'm better on Exemestane but still have some fatigue and joint pain but as my thyroid has been affected too it could be that too that's causing the fatigue and I had mild arthritis before all this which has been made worse since being on Letrozole. I didn't have a break between them as the oncologist said to just start them as soon as possible. 

    Take care. x