Letrozole and Ibandronic Acid side effects/joint ache

Former Member
Former Member
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I was diagnosed with breast cancer in February 2022. After having a single right mastectomy, lymph node removal and reconstruction surgery in March 2022 I have now been on Letrozole and Ibandronic acid for the last six months. My first lot of side effects were my knee joints. I had trouble bending my leg as it was very stiff so found it hard to kneel down and get up from the floor. Once I was up and moving around I could walk for miles but as soon as I stopped and sat down my knees stiffened up again. Not been too bad lately or maybe just getting used to it but I have now got terrible pain in my thumb knuckle/joints on both hands. For the last month I have spent most of the night with pins and needles or stiff fingers in my hand.  The thumb knuckles/joints are painful to even touch. 
Has anyone any tips or advice or even suffered the same? Will it wear off?? Any advice will be much appreciated. 

  • Hi Rach5, sorry no one has replied to you, thiss should get you bumped up to the top in the hope that you will get releevant answers.  Love from Ann

  • Former Member
    Former Member in reply to farmerann

    Hi there, sorry that have been having bad pains.

    I was the same as you on that drug. Now on excemestane (probably wrong spelling)  which has made a huge improvement :-)  it could be a suggestion for you :-)

    betsy x