Hi I had lumpectomy & radiotherapy last year & put on letrozole found my joints are very stiff painful especially in the morning very tired & also feel like I'm in a fog most of the time with hot sweats night & day. I tried exemestane but made me terribly depressed & weepy so went back to letrozole. Do the side effects ever get easier???? I'm 61 but feel 101!!! :(
Hi, sorry you're struggling with the Letrozole. I was advised that it can take up to 6 months for the side effects to settle down.
I have also heard that some people react differently to the different brands of Letrozole so it might be worth talking to your pharmacy about switching brands. The drug is the same but the other ingredients are different by brand and for some reason this seems to make a difference for some people.
Good luck
Hello
I've been on letrozole for 5 months nearly. Disturbed sleep the worst. Been listening to Dr Louise Newson podcasts, she's a menopause expert. This episode is about a lady who was having problems with letrazole and switched to tamoxifen. Worth a listen.
All the best x
Hi Pud987, I have been on Letrazole for 3 months now. I have had numerous side effects with fatigue, mouth ulcers, aches and pains and inability to sleep being the worst of them. I am hoping it is a sign things are settling but I went fior 2 long walks today without sheer exhaustion creeping inand I slept well for the past two nights. Of course I shall be unable to sleep tonight now I have said that!
Hopefully your symptoms will calm down soon.
Whatever cancer throws your way, we’re right there with you.
We’re here to provide physical, financial and emotional support.
© Macmillan Cancer Support 2025 © Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Also operating in Northern Ireland. A company limited by guarantee, registered in England and Wales company number 2400969. Isle of Man company number 4694F. Registered office: 3rd Floor, Bronze Building, The Forge, 105 Sumner Street, London, SE1 9HZ. VAT no: 668265007