Tamoxifen

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Hi guys.  I am wondering if any of you have any knowledge or thoughts on taking DIM supplements.  I am unable to take Tamoxifen as it really affected my mental health.  After speaking with my oncologist he said it is likely that all hormone type medication would probably make me feel the same way. I am worried i have no protection at all.  So i googled alternatives and found this DIM supplement, i have read some excellent reviews on them however i also seen the following..... Which has kind of put me off taking them.  Anyone had any experience with these supplements?   sorry i copied and pasted some information on it.  The part which concerns me is the last paragraph. 

 Thanks 

Kirsteen 

Xx


VITAMINS & SUPPLEMENTS

DIINDOLYLMETHANE

  • Overview

  • Uses

  • Side Effects

    Diindolylmethane is LIKELY SAFE when consumed in the small amounts found in foods. A typical diet supplies 2-24 mg of diindolylmethane. It is POSSIBLY SAFE for most people when taken by mouth short-term for medicinal purposes. Taking larger doses of diindolylmethane is POSSIBLY UNSAFE. Taking 600 mg of diindolylmethane daily has been reported to lower sodium levels in some people. 

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    Special Precautions & Warnings:

    Pregnancy and breast-feeding: Diindolylmethane is LIKELY SAFE when consumed in the small amounts found in foods. But don’t take larger amounts. Not enough is known about the safety of larger amounts during pregnancy and breast-feeding.

    Children: Diindolylmethane is LIKELY SAFE when consumed in the small amounts found in foods. But don’t give children larger amounts. Not enough is known about the safety of larger amounts of diindolylmethane when given to children.

    Hormone-sensitive conditions such as breast cancer, uterine cancer,ovarian cancer,endometriosis, or uterine fibroids: Diindolylmethane might act like estrogen, so there is some concern that it might make hormone-sensitive conditions worse. These conditions include breast, uterine, and ovarian cancerendometriosis; and uterine fibroids. However, developing research also suggests that diindolylmethane might work against estrogen and could possibly be protective against hormone-dependent cancers. But stay on the safe side. Until more is known, don’t use diindolylmethane if you have a hormone-sensitive condition
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    Firstly I am not a medical professional. But having looked at reputable sources of information regarding this on cancer websites; I see it is a food supplement and there is no evidence that it will replace a drug such as Tamoxifen. It seems that it is taken with and not instead of professionally prescribed drugs.

    Your consultant or oncologist is your best source of professional knowledge.

    When posting on this site you may wish to put a hyperlink to information rather than posting so much information. 

    You may also like to complete your profile so any medical professional on this site can see how they can help your specific case.

    Take care

    Leolady

    Life is like a boxing match, defeat is declared not when you fall ..... But when you refuse to stand up again ....... So, I get knocked down but I get up again. x

  • Hi Kirsteen78. I don't really know anything about this supplement but my oncologist has warned me against taking most supplements, other than the basic calcium, magnesium and Vitamin D. To be quite frank, I don't like the sound of it. 

    May I suggest that you post your question in the Ask a Nurse section of this site. Ellen or one of the other nurses would be best placed to answer your question properly.

    Lynn xx 

  • FormerMember
    FormerMember

    Hi Kersteen

    I’m afraid I don’t know anything about that supplement but reading the info you posted I don’t think I’d take it in the hope that it might do the same thing as tamoxifen (I am on tamoxifen so have done some research). 

    As someone has said you could ask the nurse on here or even call your breast care nurse and they could speak to your consultant??

    Hopefully you’ll find something, take care x

  • FormerMember
    FormerMember

    Hi ,

    I've spoken to our nurses about this, and John has replied:

    Hi Kirsteen,

    There isn’t enough evidence to demonstrate that DIM supplements would be beneficial. The WebMD information you posted suggests that there’s a risk that this supplement may actually be harmful in oestrogen receptor positive breast cancer – again the evidence is limited for this. If you are researching a natural approach you could consider seeing a homeopathic doctor. The British Homeopathic Association has a searchable database. MSKCC.org is another useful resource for researching herbs and botanicals. As other posters have mentioned always discuss any supplements you plan to take with your healthcare team first.

    Best wishes,

    John
    Macmillan Information Nurse Specialist

    I hope this helps. Let me know if you've got any questions as I'm happy to follow up.

    Best wishes,

    Jazmine

  • I know this is an old thread, but a valuable question. DIM or diindoylylmethane derived from cruciferous vegetables breaks down good estrogen instead of the bad estrogen. It acts as an aramotase inhibitor and stops testosterone converting into estrogen and also acts by detoxifying estrogen through the liver. I've done quite a bit of research into it, but by No means am I medically qualified so don't quote me. 

    Interesting to see the webmd article, there are women out there taking DIM to reduce estrogen dominance. I would always ask my oncologist before taking anything extra. 

    I'm on tamoxifen and am also interested in DIM. But will not take it until spoken to a professional.

    It would however, be interesting to see if any of you ladies or men have been taking DIM and have been advised to.