The ModiFY Study

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This trial is currently underway and will be opening again for more candidates in some locations in due course. I've been provided the info as I tick the boxes. It will open at my unit, Edinburgh Western.

The purpose of the study is to find out if new treatment Modi-1 can be used safely for breast, H&N, ovarian or renal cancer and benefit these types of cancer. Modi-1 is designed to help your immune system attack and destroy cancer cells.

Brief Summary: "The main objectives of this study are to assess the safety, tolerability, immunological activity, and preliminary efficacy of the Modi-1/Modi-1v vaccine, both as monotherapy and in combination with a checkpoint inhibitor (CPI) such as pembrolizumab or nivolumab (where these are standard of care in a non-neoadjuvant setting), in patients with advanced triple negative breast cancer (TNBC), advanced/unresectable human papillomavirus-negative squamous cell carcinoma of the head and neck (SCCHN), high grade serous ovarian carcinoma (HGSOC), or renal cell carcinoma (RCC)."

I'm just sharing as a heads-up, to meet others considering it, or on it. I did a search of the forum and surprisingly didn't find anything.

Coddfish over 2 years ago

I have just read the Scancell info on this and it does look interesting. Cancer Research is showing a trial of it for small cell lung cancer, but not yet for other cancers. With PD-1 positive TNBC, my next standard of care would include Pembrolizumab so this is definitely something I will follow with interest.

AnnaMary over 2 years ago

This is interesting. I don't know if I would be suitable as it has not been mentioned at any of my hospital visits. I am having palliative radiotherapy only for a squamous cell cancer which has spread from my face to my ear. I'll try and find out more about it.

Good luck with your treatment.

Mmum over 2 years ago in reply to Coddfish

There are two "arms" to it, as a monotherapy OR with nivo/pembro. clinicaltrials.gov/.../NCT0532953

Edit, link not working, trying this.

Mmum over 2 years ago

Update - just back from the introductory chat with my oncologist and signed the consent form. There's a space reserved for me so looking all good. Exciting!

Evelyns over 2 years ago

That's the hospital I attend, got appointment next month so will ask my oncologist about this new treatment .

Coddfish over 2 years ago in reply to Mmum

Really pleased you have got onto that

Mmum over 2 years ago

I've just started on the trial this week (june 2023). ModiFY Trial Day 1 The update since the injection is that my arm is a right mess!

Ulls over 2 years ago in reply to Mmum

Hi Mum, just read you post, I hope the trial go well for you. As you attending Edinburgh hospital can I ask if you are Scottish.

Catmarel over 2 years ago in reply to Mmum

Good luck Mmum

Keeping everything crossed for you

Cat x

Mmum over 2 years ago in reply to Ulls

Hiya Ulls, Yes, I'm at the Western in EDI. I'm English but regard myself as an honorary Scot, having lived here longer than the time I've lived in England (Peterborough/Southampton/Birmingham) !