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The ModiFY Study

Mmum
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This trial is currently underway and will be opening again for more candidates in some locations in due course.  I've been provided the info as I tick the boxes.  It will open at my unit, Edinburgh Western.  

The purpose of the study is to find out if new treatment Modi-1 can be used safely for breast, H&N, ovarian or renal cancer and benefit these types of cancer.  Modi-1 is designed to help your immune system attack and destroy cancer cells.

Brief Summary: "The main objectives of this study are to assess the safety, tolerability, immunological activity, and preliminary efficacy of the Modi-1/Modi-1v vaccine, both as monotherapy and in combination with a checkpoint inhibitor (CPI) such as pembrolizumab or nivolumab (where these are standard of care in a non-neoadjuvant setting), in patients with advanced triple negative breast cancer (TNBC), advanced/unresectable human papillomavirus-negative squamous cell carcinoma of the head and neck (SCCHN), high grade serous ovarian carcinoma (HGSOC), or renal cell carcinoma (RCC)."

I'm just sharing as a heads-up, to meet others considering it, or on it.  I did a search of the forum and surprisingly didn't find anything.  

  • in reply to Mmum

    I'm the other way round my birth family, are from eyemouth but I've lived in Sunderland all my life, growing up with Scott family I still have a Scottish accent mixed with mackem.

  • in reply to Mmum

    Hi Mmum, Does the Trial consist of only injections and do you know how many? If you are going to be getting it regularly maybe your oncologist would consider a Piccline or similar, it is worth asking?

    Good Luck!

    Love Annette x

    Yesterday is History, Tomorrow is a Mystery, Today is a Gift!!!
  • in reply to anndanv

    It's monthly injections or thereabouts.  I think the interval between them lengthens as we progress.  It has to be given under the skin, not IV.  It's a special needle containing  4  mini-needles and designed to deliver into the body at a 45 degree angle.  No workaround therefore.  A reaction at the injection site is "expected", I was just "surprised".  Now I'm conscious of my clothes because I don't want anyone to ask "what have you done to your arm?".  

  • in reply to Mmum

    Hi Mmum hope you don't mind me dropping into your discussion, I can fully understand you want to wear long sleeves it's bad enough having to put up with people's reactions to cancer never mind having your treatment show on your arms and having people stare at you. My spouse is a type 1 diabetic she doesn't like people staring when she has to inject herself. I hope the treatment works well for you.

  • in reply to Mmum

    Hi Mmum good luck with your trial, I hope all goes well. Heartpulse xx

    Moi

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