Antibodies thyroglobulin rising

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Hi all, has anyone had rising thyroglobulin antibodies and if so what was the outcome?

I had thyroid removed in 2018 due to papillary thyroid cancer and rai in Jan 19.

I’ve had 2 babies since and my thyroglobulin antibodies were 10

last summer and now 14

Thanks

Linda

  • Are you sure that it's the Thyroglobulin antibodies (TgAB on the blood test).?
    If it is, I'd say nothing to be concerned about.
    Tg antibodies only become an issue when they are in the thousands and even then the problem is that they mask the Tg signals rather than invalidating the tests completely.
    If it's your actual Tg that's rising, then over an extended period, it can be a sign that there are still thyroid cells in your body producing Tg. Even then, it's not a high level or a rapid increase.
    Changes of the type you describe can be explained by your doctors sending the samples to a different lab as the same sample can get different results on two different analytical machines.

    Best wishes

    Barbara

    “Scars are tattoos with better stories.” – Anonymous

  • Thanks for the reply Barbara

    Its definitley antibodies

    they said that they want to investigate further as the antibodies are making the picture unclear as to the thyroglobulin level. They’ve booked an ultrasound and waiting to hear about going for the rai scans. There was also suspected thyroid tissue on an ultrasound I had between pregnancies 

    thanks

    linda 

    Linda
    xx
    Dublin, Ireland 
  • If you were in the UK and I could be sure that your results are reported the same way as mine are, I would say your doctors are being overly cautious.

    What I can't rule out is that you might do things differently in Ireland.

    What are the quoted units for the measurement of TgAB? If they are different, we may not be talking about the same numbers at all.

    On my latest report TgAB is reported at <15.0 iu/mL

    That means that they are below the detection limit of the equipment that was used to measure them. 

    My Serum thyroglobulin level is reported as <0.1 ug/L - which again means, below the detection limit of the equipment.

    The only way I can see 10 going to 14 being an issue is if your lab is measuring by different units.

    I've always been told that for TgAB to be an issue, and measuring in the UK standard way, the antibodies have to be in the 100s or more likely 1000s for them to interfere with the detection of Tg.

    Normally, high antibodies - and I wouldn't say yours were high - are a sign of an autoimmune thyroid condition like Hashimotos.  

    Even when high antibodies are measured, some labs are able to measure Tg using a test where they pre-centrifuge the sample to separate out the antibodies and give better access to the Tg itself. 

    Best wishes

    Barbara

    “Scars are tattoos with better stories.” – Anonymous