Thyroid Nodule – TIRADS 4 Ultrasound + Bethesda 3 AUS Biopsy – surgery?

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Hello there,

I am new to this forum and am looking for some additional advice and perspectives (I plan to seek a second opinion though with a specialist).

I'm a 43 year old female.

I have more than one thyroid nodule, one of which was rated on ultrasound as TIRADS 4 with moderately suspicious features including hypoechoic, hyper/central vascularity and micro-calcifications.

An FNA biopsy came back as AUS (Bethesda 3) with less pronounced cellularity, showing thyrocytes and also Hurthle cells, single and in smaller clusters, with nuclei slightly enlarged and "moldy to each other" (nuclear molding?), but with regular contours. Vesicular chromatin. Cytoplasm moderately abundant and basophilic. The smear also contains rare macrophages, colloid and degeneratively changed cells.

I do not have Hashimotos or autoimmune thyroid (ruled out from previous blood work).

I also have a slightly high Thyroglobulin (89.26 ng/mL) and my grandmother had thyroid cancer (not sure which kind). I also have high TSH with normal T3/T4.

The largest nodule which was biopsied above is 48x19x19 mm. They are saying that given the imaging is moderately suspicious and now biopsy shows atypia, that I should have a total thyroedctomy (also for definitive diagnosis).

I want to understand if this is the best course of action?

Also, does this raise the likelihood of malignancy?

They say repeat FNA not advised and molecular testing is not available where I am (I am outside the US).

Thanks for your feedback in advance.

Best,

MJ

  • Hi  and a very warm welcome to the online community which I hope you'll find is both an informative and supportive place to be.

    I’m Anne, one of the Community Champions here on the Online Community and, although I'm not a member of this group, I noticed that your post hadn't had any replies yet. Responding to you will 'bump' your post back to the top of the discussion list again.

    While you're waiting for replies, it would be great if you could put something about your diagnosis and proposed treatment into your profile as it really helps others when replying to you and also when looking for someone on a similar pathway. It also means that you don't have to keep repeating yourself. To do this click on your username and then select 'Profile'. You can amend it at any time and if you're not sure what to write you can take a look at mine by clicking on my username.

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  • Thanks a lot! I've included most of it in my message above but I will also add it to my profile, thanks.

  • Thanks. You could copy and paste your post into your profile :)

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     "Never regret a day in your life, good days give you happiness, bad days give you experience"

  • Just gently bumping this thread in case anyone has any perspectives to share. Thank you!

  • Hi MJ311,

    I feel like I am in a similar situation, my biopsy showed cells in the left half that were abnormal but they can't tell me whether or not they are malignant without taking out half or all of my thyroid. They seem to be leaning more towards removing the whole thyroid as I have a large nodule (on the right half) which will most likely keep getting bigger regardless of whether it is cancerous or not.

    I feel slightly like I'm having to make the decision, I have asked to have another ultrasound scan in three months so I can have a think in between but I am now considering having my thyroid removed in case it is cancerous. I am debating getting a second opinion and seeing what another specialist suggests.

  • Hi latchbrook,

    Please I need a second opinion and advice. I had hemithyroidectomy ( right ) 4 weeks ago. During the procedure the nerve on my voice box was damaged unfortunately. I have a weak voice and hoarse voice and by the end of the day I’m almost whispering. After the surgery during follow-up appointment I was told that 2 foci found in the area ( 5mm tall- cell variant and  2mm follicular variant ) when pathology result came- it didn’t spread , it says pT1a (M). Now they are offering me completion thyroidectomy this January 2025. I can’t decide on whether to have the surgery soon and why is it necessary to remove the other one when they said that it hasn’t spread. What options do I have? I’m worried about the long term side-effects or the risks of another surgery. Please help. Thank you

  • Hi  

    I'm afraid I don't have any personal experience with thyroid cancer so it might be best to start a new post in the group asking for people to share their experiences with you.

    I also haven't had a second opinion but this information from Macmillan on getting a second opinion will give you information on how to arrange one.

    Wishing you all the best

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     "Never regret a day in your life, good days give you happiness, bad days give you experience"

  • Hi latchbrook,

    Thanks for replying anyway.

  • Hi, 

    I'm sorry you are going through this.  I am in a similar situation. I have Hashimoto's and a Thy3a nodule on my left side and multiple U2 nodules through out. I am going to discuss a removal of my left lobe as I had two FNAs already (thy1 and Thy3a) the way I see it I rather take it out as I already have to take medication due to Hashimotos and at least it could give me a definitive answer. Sharing a picture of my FNA results.

    I think you need to consider carefully as I understand you are not currently on meds for thyroid which you will be after. But also what would give most peace of mind.

    Good luck and keep us posted