Clinical trials

Hi Fzh2p0 ,

Before any decision we would make we would read further into each and then make an informed decision . 
You haven’t said what stage your PC is at . My OH is not on a curative pathway so any trial dealing with lymph nodes we would be inquisitive as he only has one inquinal lymph node outside his pelvis that they won’t treat . The other lymph node is within the pelvis . 

take time and read up any literature on the trials before you make any decision

Best wishes

Liz & OH xx

Hi Fzh2p0 and welcome. Can you clarify what the Astrazeneca trial is and this might help you get a response from someone who is on that particular drug. I have done a quick trawl and it looks as if it might be the ASCERTAIN trial (NCT05938270) which is assessing either an already approved hormone therapy (Darolutamide), a new PARP inhibitor or a combination of the two. Any trial comes with a risk and possible side effects which only you can decide whether you want to participate but make sure you understand what you are being asked to take and for how long.

That’s the one. Darolutamide, Saruparib or both. 

I used to work in the clinical trials industry and have asked around my contacts and the feedback has been generally positive. Especially as the short dosage time means the side effects are minimal. 

It’s just new being on this side of the trials fence. So was wondering if anyone else has been thinking of taking part in anything.

Its a phase 1 trial, but Saruparib has been around for a few years now, so not a very early high risk part of the phase

Got loads of Literature and am quizzing contacts in the clinical trials industry. It’s just all a bit daunting. 

I have localised PC which the surgery team think can be fully removed. But as it’s Gleason 5+4 they need to get on it fast and have potential trials that may benefit. 

Definitely not leaving lymph node to chance , that a discussion with the consultant. The MRI is fine, and the AZ drugs I’m tending towards yes. 

Thank you for taking the time to reply. And wishing you and your OH the best possible. 

I presume you have done your research into the risk of recurrence with a Prostatectomy depending on initial staging and type of procedure. From my understanding the PARP inhibitors boost the immune system whereas the Darolutamide is a hormone therapy which rapidly reduces testosterone levels.

We have a few who have been on the PACE NODES trial SBRT or are currently being offered a variation of it.

 PACE NODES trial 

 RE: Pace Nodes Trial 

Also PEARLS trial.

 Pearls trials with extended lymph node radiotherapy.

If anyone is interested in finding out about clinical trials for prostate cancer here is the link.

https://www.cancerresearchuk.org/about-cancer/prostate-cancer/research-clinical-trials

Thank you Alwayshope 

I’ve restarted looking for a trial re the inquinal lymph nodes we would. This will allow me to challenge the Oncologist as we mean business to try for a curative pathway. 

how are you both ?  It’s funny I was thinking about you both this morning and was going to message you. Xx

We are fine thanks Liz but radiotherapy to the thigh starts on Monday now and probably for 10 days. All is organised for our 'holiday' in Athens. I am still trying to drill down the what next to deal with the rest of the mets.

Hi 

you know me looking for answers .

Have you seen anything on these. as I’m still looking & praying they can put OH on a curative pathway  

ipilimumab

Histotripsy

You probably have seen and dismissed .

hugs to you both xx