For some time now my lower legs have been ‘twitchy’ late in the evening if I have been sitting down for a while.
More recently a number of small, red lumps have appeared on both legs which I would describe as hot and very itchy, which I put down to insect bites after working in the garden one day. They have been there for a couple of weeks now with little change.
I’m 9 months post-pelvic RT (lymph node involvement), on 3-monthly Zolodex LA injections, Apixaban (anti-coag), a statin and AdCal D3. Just curious if these could be a side-effect of the drugs - or have I become more attractive to insects?
Has anyone else also experienced these things?
Hello Amplitude
Good question - I can't answer it fully but 3 months after radiotherapy I developed a full body "itch". I spoke to the team at Christies and they said is was a reaction to either the RT or HT (Decapeptyl). I was prescribed some E45 cream.
The E45 didn't quite hit the spot but a cream called Aproderm and Childs Farm Baby Moisturiser did. It took about 3 months to fully settle down. I still use Aproderm on rough skin on my feet!
My team do recommend I let them know of any changes to my general health (they diagnosed a rotator cuff issue for me as I thought it was the cancer!) - I think I would have a word with your oncology team on Tuesday.
Kind regards - Brian.

Macmillan Support Line - 0808 808 00 00, 7 days a week between 8am-8pm
Strength, Courage, Faith, Hope, Defiance, VICTORY.
I am a Macmillan volunteer.
Hi Amplitude , early on in my treatment I had itching and red spots. I saw a dermatologist who suggested I change from standard shower products to QV gentle. I get this from Boots (other pharmacies are available). My skin is much thinner than it ever was (poss chemo, RT, HT or old age) and I think reacts badly to sunlight, so I try and use factor 50 whenever possible.
Best wishes, David
Please remember that I am not medically trained and the above are my personal views.
Thanks gents Millibob , David2017 . This afternoon I counted 23 of these itchy bites/lumps, although for some reason it’s only my right leg which is really itching today.
I found some years ago that softener in the washing machine and some shower gels cause a skin reaction on my lower legs, so avoid those now. They have also been out in the sun a bit recently, which sounds like it could be a factor too? I will have a look for the recommended Child’s Farm, QV and E45 products tomorrow, see if they improve things.
Hi Amplitude,
If it's a chemist you pop into to purchase these, I would suggest you ask to speak to the pharmacist & they can have a look at the rash.
The reason I suggest this is the day before my 70th birthday in March I developed shingles (typical of me it was one day before I became eligible for the jab). Don't laugh, but the rash was on my right buttock! So, off I trotted to the chemist with a photo my husband took of the offending cheek & showed it to the pharmacist (far less embarrassing that way) who confirmed it was shingles. They were able to give me an immediate prescription for anti viral tablets which helped clear things up quite quickly with minimal discomfort.
Best Wishes
Brian
Whatever cancer throws your way, we’re right there with you.
We’re here to provide physical, financial and emotional support.
© Macmillan Cancer Support 2026 © Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Also operating in Northern Ireland. A company limited by guarantee, registered in England and Wales company number 2400969. Isle of Man company number 4694F. Registered office: 3rd Floor, Bronze Building, The Forge, 105 Sumner Street, London, SE1 9HZ. VAT no: 668265007