IRE - Gleason 4+4 retuned as 4+5

Have you tried swimming? Low impact. 

Hi James thanks letting me know, is that IMRT? and whats the criteria for giving it do you know?

Hi James thanks for your info, well aware of the dangers with Gleason 9 below is what I'm thinking about at the moment, it's fairly bloodless which is appealing. It sees to me with these things it's a bit like buying a lottery ticket you pay your money and take your chance.;

IRE with Electrochemotherapy (IRECT) of the prostate - a gentle treatment option for advanced cancers and complex recurrence tumours

IRECT is a new form of therapy to treat prostate cancer. It extends the IRE treatment area, in which the cells get destructed shortly after the treatment, to a zone in which Reversible Electroporation (RE) occurs (figure 1). In the area of RE we additionally apply Electrochemotherapy (ECT).

The efficiency of Bleomycin is multiplied in the RE treatment area. This occurs due to the increased permeabilization of the cell wall caused by electroporation, which allows an increased uptake of the chemotherapeutic drug into the tumour cells (figure 2). This technique is already successfully in use for the treatment of skin and bone tumours.

Bleomycin is a chemotherapeutic drug which can be applied to the treatment of malignant tumours and has been in medical use for many years. An effective treatment with Bleomycin alone normally requires several applications.

The increased effectivity caused by the Bleomycin extends to the IRE treatment area margins, in which the reversible pore formation is initiated. Without Bleomycin the Reversible Electroporation in these areas alone is not sufficient to cause cell destruction.

Using IRECT therapy is a new method to treat cancer cells in more distant areas from the IRE electrodes, without causing damage to local organs (e.g. the rectum and bladder sphincter) or tissue. It is therefore the most gentle way of treating large tumour areas.

Indications for carcinoma treatment using combined IRECT therapy

To date the indications for the combined treatment of IRE and Bleomycin are not fully clarified and research is continuing in this area. Only those patients refusing alternative treatment will be treated. Possible uses include:

Patients with high-grade prostate carcinoma
Patients with prostate carcinoma which infiltrated the rectum or bladder wall
Patients with beginning infiltration of the sphincter, which could lead to incontinence
Patients with complex focal recurrences after surgery, HiFU or radiation
Patients with metastases in lymph nodes, bone or in specific cases also metastases in other organs
Treatment procedure

When the IRE needles are positioned, Bleomycin will be injected. After only 8 minutes the Bleomycin is already distributed throughout the body. Localised and short electrical currents will be applied, producing both the IRE and RE fields. Within the IRE field, all tumour cells will be destroyed immediately afterwards. In the RE field, the tumour cells have a very high Bleomycin uptake, causing them to die within a few hours.

After the procedure is completed, you will remain under stationary treatment for one night and can leave the hospital the day after. You can return to everyday life a few days afterwards.

Thanks Des,

Were the heart problems connected to the HT do you think? I'm guessing sex is out of the question whilst your on HT and coupled with all the other downsides I'm trying to resist until absolutely necessary

Cheers

Billy

H Steve thanks for this mate, I've had several opinions now, I'm leaning toward another round of IRE but this time with a local dose of chemo applied to the prostate;

IRE with Electrochemotherapy (IRECT) of the prostate - a gentle treatment option for advanced cancers and complex recurrence tumours

IRECT is a new form of therapy to treat prostate cancer. It extends the IRE treatment area, in which the cells get destructed shortly after the treatment, to a zone in which Reversible Electroporation (RE) occurs (figure 1). In the area of RE we additionally apply Electrochemotherapy (ECT).

The efficiency of Bleomycin is multiplied in the RE treatment area. This occurs due to the increased permeabilization of the cell wall caused by electroporation, which allows an increased uptake of the chemotherapeutic drug into the tumour cells (figure 2). This technique is already successfully in use for the treatment of skin and bone tumours.

Bleomycin is a chemotherapeutic drug which can be applied to the treatment of malignant tumours and has been in medical use for many years. An effective treatment with Bleomycin alone normally requires several applications.

The increased effectivity caused by the Bleomycin extends to the IRE treatment area margins, in which the reversible pore formation is initiated. Without Bleomycin the Reversible Electroporation in these areas alone is not sufficient to cause cell destruction.

Using IRECT therapy is a new method to treat cancer cells in more distant areas from the IRE electrodes, without causing damage to local organs (e.g. the rectum and bladder sphincter) or tissue. It is therefore the most gentle way of treating large tumour areas.

Indications for carcinoma treatment using combined IRECT therapy

To date the indications for the combined treatment of IRE and Bleomycin are not fully clarified and research is continuing in this area. Only those patients refusing alternative treatment will be treated. Possible uses include:

• Patients with high-grade prostate carcinoma
• Patients with prostate carcinoma which infiltrated the rectum or bladder wall
• Patients with beginning infiltration of the sphincter, which could lead to incontinence
• Patients with complex focal recurrences after surgery, HiFU or radiation
• Patients with metastases in lymph nodes, bone or in specific cases also metastases in other organs

Treatment procedure

When the IRE needles are positioned, Bleomycin will be injected. After only 8 minutes the Bleomycin is already distributed throughout the body. Localised and short electrical currents will be applied, producing both the IRE and RE fields. Within the IRE field, all tumour cells will be destroyed immediately afterwards. In the RE field, the tumour cells have a very high Bleomycin uptake, causing them to die within a few hours.

After the procedure is completed, you will remain under stationary treatment for one night and can leave the hospital the day after. You can return to everyday life a few days afterwards.

Hello Billy

nanoknife didn’t work for me either.   My op was March 2018     3+4 =7  on a 9mm tumour contained in gland.  Post op PSA rise over next 12 months and then a suspect area turned out to have cancer cells at same grading as before this time 3mm. my nanoknife did not get every cell with some left behind.

Now when I go exploring others experiences everyone is pleased for first 6 to 12 months and then reoccurrence.

It’s hard to get a clear picture as I’m sure anyone who has a successful experience of nanoknife will just go quiet on this platform and get on with their lives. 
Im wondering if everyone who gets nanoknife will in-fact have a recurrence.  just perhaps this procedure does not work. If this is the case then it is important to get the message out there for future guys who find themselves in our position.

what do you think 

glasgow1964

Sadly I think you may be right Glasgow, I used to think it maybe symptomatic of focal therapy (the surgeon ablating as little as possible in order to do the least amount of Damage) But I met a couple of guys in Offenbach with a 12 month reccurence in the seminal vesicles who, like me, had the whole prostate ablated.

The story they told me in Offenbach was that they got similar success results to Prostatectomy without the downside of Ed or incontinence. When I asked them if I could see the published results they said they were about to publish, which significantly they have never done, in itself is odd I think, You’d think if that was the case they’d want it published wouldn’t you?

Good luck anyway Mate let me know how it goes.

Cheers

Billy