Brother diagnosed with advanced prostate cancer

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My brother (67) received his diagnosis of advanced prostate cancer yesterday. PSA of 856 (how is that even possible?), spread to lymph nodes, seminal glands and large area of bone structure. Not sure what the gleason score is yet but will surely be a 9.

I am the sensible, voice of reason sister so want to get the tone right between being realistic and helping him with acceptance/putting things in order versus hope with the treatment pathway. The treatments seem really awful and he is already in quite a bit of pain so am not sure about his resilience with all this. I want him to know its ok to say when he has had enough but also give him encouragement at the right times. He has a partner but she has her own physical and mental challenges and is mostly wheelchair-bound so they could both do with support.

Reading back, I'm afraid I have made this all about me but just want to get tooled up for the road ahead.

Thank you for any advice.