Perineural Invasion

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Hi,

I recently had a template biopsy in August, one year after my original Gleason 6 diagnosis in August 2024.

My cancer has been upgraded to Gleason 7 (3+4) and the biopsy report noted ‘‘a focus suspicious for but not definite of perineural invasion’. However, the consultant’s letter which says ‘There was also evidence of perineal nvasion’ (I assume ‘perineural invasion’?).

‘Suspicion’ to me means that something might be the case, whereas ‘evidence’ means that it actually is.
So have I got PNI or not? Should I worry about PNI and is the outcome going to be worse for me?
I am scheduled to undergo a RALP in two weeks time.
Thank you
  • Hi Andy and welcome 

    A little bit surprising that a few months ago MRI showed tumour up about 10mm and they went ahead with another biopsy.

    I would have thought straight into treatment, I presume the MRI showed near the capsule edge?

    However even if just broken through still treatable/curable and Gleeson not too high.

    So all the best for the coming op

    Steve 

  • Hello Andy ( 

    In simple terms perineural invasion means the cancer cells have attached themselves to a nerve/nerves running through the prostate. 

    Perineural invasion means the cancer may well be more aggressive and more likely to attempt a breakout as it can use the nerves as an escape route.

    Your Gleason Score has already been upgraded so the evidence is there - not to worry though, the who job lot is coming out in a couple of weeks time and with luck it's still all contained. As with any surgery once the prostate is removed and on the lab bench it will be checked to ensure all the margins are clear.

    It sound like your team have everything in hand - get your pelvic floor exercises sorted out and look forward to a cancer free Christmas.

    Best wishes - Brian.

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