Starting triplet therapy - question about prognosis

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Hi all,

Brief recap:

Diagnosed Feb '25 - Gleason 8, PSA 35.

Radical prostatectomy with Lymph Node removal Jul '25. Upgraded to Gleason 9 post op. Lymph nodes all clear.

PSA 4.3 at initial review meeting, suspected metastatic spread. 2nd PET scan requested. Started Bicalultamide 

Metastatic cancer found from PET scan - Sep '25. Initial Prostrap injection Oct '25

Due to start Triplet therapy Nov '25 (Darolutamide and Docetaxel) + Bisphosphontes and ADCAL

I was after some thoughts on my second meeting with my oncologist - he told me that the PC has indeed spread to my lungs (and now to my pelvis - 1 small area) but not my liver as thought - he still recommended the triplet therapy as we discussed last time.

My PSA has only dropped to 4.2 following a month on Bicalultamide and 2 weeks after the Prostrap injection..should I have expected more?

I have read a few posts/bios on Triplet which have been very helpful and I am feeling confident about starting. My wife is half way through her chemo and coping well, bless her.

The Oncologist said my life expectancy should be around 6-years (average) which was a bit of a shock - although he did say he hoped I would live longer than that.

I am (and my family are too) a bit worried about the 6-year timeframe...I am not sure how to process that information - other than to plan some holidays post chemo...

I think I am just going to ignore the timeline and carry on with life and do as much as I can over the next few years.

How have you dealt with this kind of information?? 

  • In my view of my situation, not yours, I will keep positive and doing what I can until I can’t.

    As for you and your positive attitude, I’m certain whatever the life expectancy may be it’s yours to enjoy so enjoy it. We are all so very different in make up and mental attitude so there’s no slide-rule of expectations.

    Keep it simple. Wake up, get up, eat up, get out, do stuff, eat more, have a drink, go to bed, go to sleep.

    Simples…

  • Keep it simple. Wake up, get up, eat up, get out, do stuff, eat more, have a drink, go to bed, go to sleep.

    Exactly!

    Do some of what you like, some that will help others, other things that feel important to you.

    If you want to cheer yourself up, do some research about how prostate cancer treatment has moved forward in the last fifteen years.

    Steve

    Changed, but not diminished.