PSA accuracy

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Hello there. 

Just after a little bit of reassurance please. Since my husband’s reoccurrence of PCa last year, he has been on Enzalutamide and 12 weekly Zoladex. His PSA was 6.8, which triggered the latest investigation, and since commencing treatment it has been steadily reducing. 

He had an GP MOT blood test in late June which, amongst other results, happened to show his PSA now at 0.17 - which was great news. However, he had his regular 2 monthly appointment with oncology a couple of weeks later and his PSA was 0.19. The consultant didn’t seem bothered at all at a difference of 0.02 so I should just stop fussing and assume that’s a ‘normal’ slight anomaly?

His latest Zoladex injection was actually due on the day of his latest test, so is it possible the effect from the previous implant was just started to wane anyway?

Many thanks! 

  • Overthinking is a natural habit and any reduction or increase in blood tests results can cause sleepless nights. The latest trend is up but if you look at the number it’s very low. My advice is to wait and see and enjoy the fact that it is very small currently. In time the PSA will be one of the many indicators you will worry about. Relax for now, if you can.

  • Hello  

    The normal rules for intervention is when PSA rises 2 whole points or you have 3 consecutive rises in 3 tests. There are of course agreed exceptions to these rules (I have a rising PSA and have agreed to wait until it's 10 before intervention).

    A rise from 0.17 to 0.19 is nothing and could be caused by many outside factors - too much exercise or sexual activity in the past 48 or even the samples being tested under different laboratory conditions.

    He's doing great - enjoy life and try not to worry (I know it's easy for me to say!!).

    Best wishes - Brian.

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