MRI report

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Can someone help me understand my husband MRI report please? 

How serious is this please

His PSA is 4.86

But the MRI report seems indicating high grade cancer and almost entire occupy the prostate?? His biopsy is not until the end of the month! so 3 weeks from now!! Waiting is killing!

He is in othewise very good health condition and 67 and his parents recently passed at age 92 and 94 so I am hoping that he inherited the family long life gene!

PROCEDURE: MRI PROSTATE W WO CONTRAST 
 
HISTORY: Elevated PSA. Most recent PSA 4.86 ng/mL on 10/24/2024.  
 
TECHNIQUE: Multi-parametric 3.0 Tesla MRI was performed using a torso phased-array coil, including multiplanar T2-weighted images, axial T1-weighted images, axial diffusion-weighted images, and volumetric dynamic post-contrast images of the prostate. Axial in-and-opposed-phase gradient-echo T1-weighted images and pre- and post-contrast fat-suppressed gradient-echo T1-weighted images of the entire pelvis were also obtained using the "Prostate with Contrast" protocol. 
 
 COMPARISON: None. 
 
 FINDINGS: 
 Prostate size: 4.6 x 3.7 x 3.9 cm for an overall volume of 35 cc. PSA density: 0.14 
 
 Tumor localization: Lesion 1 in the transition zone PI-RADS assessment category: 5, Very high probability Appearance on T2-weighted images: 5, lenticular or non-circumscribed, homogeneous, moderately hypointense, and >1.5 cm in greatest dimension, or definite extraprostatic extension/invasive behavior Appearance on diffusion-weighted images: 5, focal markedly hypointense on ADC and markedly hyperintense on high b-value DWI; >=1.5 cm in greatest dimension, or definite extraprostatic extension/invasive behavior. This lesion has a low ADC value of 0.4 Appearance on dynamic post-contrast images: Positive - focal enhancement directly corresponding to the suspicious finding with early or contemporaneous enhancement to normal prostate 
 
Size: 1.8 x 1.2 cm, series 17 image 14 (T2) 
Side: Right 
Zone: Transition 
Level of prostate: Predominantly mid gland (nearly involving the entirety of the anterior transition zone) 
Location within transverse plane: Anterior 
Extraprostatic extension: Abuts the prostatic capsule 
 
Additional peripheral zone findings: Linear or wedge-areas of decreased signal on T2-weighted imaging with associated diffuse increased perfusion, suggestive of prostatitis. Additional transition zone findings: Enlarged and heterogeneous with circumscribed nodules consistent with benign prostatic hyperplasia. 
 
Extraprostatic extension: None. 
 
Seminal vesicle invasion: None. 
 
Lymph nodes: No pelvic lymphadenopathy. 
 
Osseous structures: No aggressive osseous lesion. 
 
Additional findings: The urinary bladder is unremarkable. There is a 0.6 cm prostatic utricle cyst. 
 
IMPRESSION: * 1.8 x 1.2 cm right anterior predominantly mid gland (nearly involving the entirety of the right anterior transition zone) transition zone lesion, corresponding to an assessment category of PIRADS 5 - Very high (clinically significant cancer is highly likely to be present). This lesion abuts the prostatic capsule with a low ADC values of 0.4 suggestive of a high-grade tumor. 
 
* No lymphadenopathy. 
 
The prostate gland was segmented and the suspicious lesion(s) were annotated on the DynaCAD system for UroNav guidance. 
  • Hi  E 

    I am no expert on MRI wording but tend to look for tumour size and location within the gland

    So size in cm fairly large in fact similar to mine just before I started treatment. Mine was also near the gland edge.

    I presume no biopsy yet?

    I would think that treatment should start soon possibly after biopsy, have they talked about that yet?

    Best wishes 

    Steve 

  • Good afternoon,  ,

    This is a forum that no one ever wants to join, but most of us are quite glad to be here. Welcome.

    None of us are medically qualified.

    On first reading this report is better than my own.

    It is highly indicative of cancer, BUT it does not appear to have escaped from the prostate capsule and gone walkabout.

    If this is the case, it is possible that the main problem you and your husband will have is deciding which treatment is possible. Now that a couple of us have answered, you are likely to get more experts pop up shortly.

    Best wishes,

    Steve

    Steve

    Changed, but not diminished.
  • Hi Steve,

    Thanks for replying. The waiting game is killing me. The biopsy is scheduled to be the end of the month! 

    I know the size seems very large and that really concerned me as well as the high grade!

  • Hi Steve,

    Thanks for your reply! Yes we want to start treatment as soon as possible and I hope surgery can cure it?? That is what I read online. Hope that is the case. 

  • I suppose the surprising thing is the PSA relative to the size, some low PSAs can indicate a more aggressive kind of cancer which the report does talk about'.

    In a way it's a shame HT can't be started soon to stop any growth in its tracks.

    Have they talked about treatment, in this particular case RT and HT could be the best option but obviously I am not an expert or even a Dr.

    Hope all goes ok and keep us posted 

    All the best 

    Steve 

    Ps is that the only PSA or are there previous ones?

  • Hi Steve

    What is your PSA level prior the treatment? You said yours size is about same as his? Thanks.

  • My PSA went from about 4 to 13 over 4 years on active surveillance.

    Tumour size went from 3mm to about 1.3 cm over the same period, near the gland edge in the end

    But a Gleeson 6 which is non aggressive so that is y Active surveillance for 4 years

    Steve 

  • Hi  - this looks like a curable cancer to me.  It does not “occupy the entire prostate”:  it occupies “the entirety of the anterior transition zone”, which is just one of many zones, ranging from base, mid, apex, lateral, medial, transitional, etc. 

    So, please try to control your fear (I know, it’s difficult), but looking at that MRI report, which is very technical, his cancer has been caught early and it appears to be confined to the gland.

    Also, please don’t jump straight to surgery as the best option.  I know it’s natural to just “want it out”, but you need to think hard about side effects and cure rates.  You need to discuss this with an oncologist as well, as there are also other extremely effective treatments available.

    Read some bio’s on here and see how other men have fared.  The Bio is the icon next to the name, click and read.    AW

  • Hi Alpine, 

    Thank you for the detailed reply I really appreciate it! Thank you! yes I am really scared... the wording on mri report are so complicated and all I know is agreesive high grade and large size tumor. However the psa is not extremely high but who knows. And biopsy is not until 3 weeks later....

    Thanks again!

  • Hello  

    Another warm welcome to the Macmillan Online Prostate Community. I am Brian one of the Community Champions here on the Community. I also have Prostate Cancer.

    First off none of us are medically trained as this is purely a peer to peer forum.

    Having read through your post the MRI indicates there is cancer showing in the Prostate and it is wholly contained within the Prostate.

    From my understanding of what I know (I have been wrong before) time is on your hands and you are following the usual diagnostic path. The biopsy will give the formal diagnosis, your urology team may ask for a bone scan to check all is well and then there will be an MDT meeting at the hospital to decide on the treatment path.

    The treatment options in your husband's case should be :- Surgery to remove, Hormone/Radiotherapy, Radiotherapy or Brachytherapy all I expect to be with a view to being curative.

    Personal advice, relax, get on with life as much as you can, stay well away from Dr Google and if you are going to search out any information use only trusted sources, Macmillan, Prostate Cancer UK, Cancer Research or ask questions here.

    Ask any questions you need an answer for - nothing is too trivial.

    Here's a link to start you off - The Prostate Biopsy.

    If I can do anything else for you please do let me know.

    Best wishes - Brian.

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