Prostate cancer with bone metastases

I am in a similar boat
I was diagnosed in June/July 2023 , put on 3 monthly Triprorelin injections and did a course of Docetaxel as well.
My PSA dropped from 383 at diagnosis with mets to bones and lymph nodes to below 1
I has recently started rising again. Doubling every 3 months from Feb this year but is still below 1 but the consultant have decided to put me on Olaparib and Abiraterone as an additional treatment to try to get the PSA going the other way.  I haven't started these yet - I'm waiting for the hospital to get in touch.

Is there a reason you weren't put on the 3 monthly HT injections as it seems pretty standard practise?

Hello Clamp and welcome to you and your wife. My husband does not have bone mets but he is T4 with distant mets diagnosed initially in 2020 and we have gone through 3 recurrences to date so I can understand your fears. We all follow the PSA and dread when we see any kind of rise but have to rely on the experts to know what this means. I have attached an article which reports on a case similar to yours where the PSA reduction was not seen until after more than 10 cycles of Cabazitaxel and the figures are of the same order.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585438/

What I would also encourage you to do is to watch a video which I use as a reference explaining treatments available and when to use them. There is another targeted bone therapy called Radium 223 which you might be eligible for plus I would ask if you could have genetic screening which might open up other treatments like PARP inhibitors, immunotherapy.

https://youtu.be/-RVVq0uDAEE?si=orMAoZ7jMMX2QsMx

There are different types of hormone therapy but what might be suitable will be determined by what you have already had. It might help if you put some basic information on your profile page outlining the therapies you have had to date.

Please come back with any questions and we will try and help. If you need help emotionally then Macmillan have a support line on 0808 808 00 00 but they also can organise some free BUPA counselling sessions if you think they might be of use.