Does Denosumab have serious side effects?

Hi Warrior68 

My husband has been on this for the last 4 years. He has been prescribed Xgeva 120mg every 2 months which I prepare for him and he injects it himself into the stomach. He also takes calcium and vitamin D but I make sure that his supplemented calcium does not exceed 1000mg per day. To be honest he hasn't noticed any difference from the side effects he gets from the hormone therapy but the major side effect to watch out for is osteonecrosis of the jaw (4 cases per 100000 patients). His calcium levels have remained stable for the whole time. He has had no broken bones even though he has had falls. There are different dosing recommendations for different versions e.g. Prolia is given once every 6 months.

An alternative is biphosphonates.

Hi thanks for your reply. Its a very useful info.

As u said the other option is bisphosphonates. I plan to seek an opinon from an orthopedic before taking the denosumab shot.

I consulted my orthopedic to discuss the options to prevent osteoporosis, and acc to him denosumab and biaphosphonates have side effecta and hence he is prescribing me parathyroid hormone therapy( (Peritaride) which is to be taken as a SC injection daily for atleast 3 months.

This acc to him is the safest med to combat the bone thinning side effects of abiraterone and prednisone treatment.

Does anyone have any exp with this therapy?

Hi Warrior68 .

It is always good to consult the experts. The drug I think you have been prescribed is Teriparatide. I have no experience with it so it would be useful if you could keep us updated on how you get on with it. This is a fact sheet from the osteoporosis society.

https://theros.org.uk/information-and-support/osteoporosis/treatment/teriparatide/

The NHS state there is enough evidence at the moment to recommend it for the use in men at risk of bone thinning.

Hi

Thanks for the info. The link u provided was very helpful.