Carcinoma vs adenocarcinoma

That’s a very good question Phitowel, for which I don’t have an answer. I have adenocarcinoma with aggressive traits (AIP and cribriform seen on biopsy) and my PSA plummeted from 13 to 0.29 in 10 weeks.  It has continued down after radiotherapy and now sits at 0.07, seven and a half months into hormone therapy. I’m hoping that it will continue down as the nadir (post radiotherapy) is not due for another 15 months.  Good luck with your research.    AW

Hello Phitowel .

Carcinoma is another word for cancer in general. I have attached a link to the different types of prostate cancer which shows where they originated from so no, carcinoma does not mean neuroendocrine.

https://www.cancerresearchuk.org/about-cancer/prostate-cancer/stages/types

Neuroendocrine tumours can develop in many different organs of the body and affect cells that release hormones into the blood. From what I have read it appears that neuroendocrine prostate cancer often results as a consequence of resistance to the first line of treatment but can more rarely be identified at initial diagnosis, such as small cell. I have attached a review.

www.ncbi.nlm.nih.gov/.../

Finally I have added a link to current and emerging treatment for neuroendocrine prostate cancer.

https://www.sciencedirect.com/science/article/abs/pii/S0163725822001498#:~:text=De%2Dnovo%20NEPC%2C%20the%20other,et%20al.%2C%202021).

Generally treatment of the rarer prostate cancers is challenging because there are fewer instances of them so less experience. It is also rare that they exist in isolation, but usually form part of a mix with the more usual adenocarcinoma so traditional therapies have to be used alongside more aggressive treatments against the aggressive characteristics. Radiotherapy does seem to work with these rarer cancers but I haven't seen any evidence that it works better for them compared to adenocarcinoma - this is a question for the experts. 

Thanks Alwayshope for your reply! 

Afternoon all this is a great read and very interesting,I didn’t realise there were so many types ,the information we get on here is second to none️

Wow - thanks for that answer Alwayshope - you do accept any challenge set on the forums - it's great to have your knowledge and research skills.

It's much appreciated - Thanks - Brian