Rising PSA after Salvage Radiation

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17 Months ago I had a Robotic Prostatectomy done. PSA after procedure was 0.06.Three months later it was 0.16. Due to my age and pathology report I was referred to an oncologist. Gleeson 8 Stage 3a. 

Salvage radiation followed in September 2022 with 35 sessions on my prostate bed and lymph nodes combined with Luprin over 6 months. By March this year my PSA dropped to 0.009 and Testosterone below 1. Six months later and my PSA has increased to 0.086 and my Testosterone to 18. 
My next blood test is in 3 months time.

Has anyone else walked down this road? What is the likelihood that my PSA will come down naturally? As I understand it PSA should not climb after all the work done without a prostate, indicating cancer somewhere.

Kind Regards

Munster

  • Hi  well, well, it looks like your radiography team are sharp shooters and they sent those rogue cells packing Stuck out tongue winking eye     AW

  • Hi All,

    I have just had an appointment today 31 July 2025, 5 months after my last appointment in February 2025. I had to travel to Thailand and Bali for 3 months for work - took my mind off the little medical problem I have, which was great.

    A year ago I had 3 SBRT sessions each on my T4 and C5 vertebraes. It is a relief to see that my PSA has dropped from 0.13 ng/dl to 0.097 ng/dl, even though I expected it.

    I am still not on any other medication and doing realy well, such a relief. This has been my choice and thus far seems to be working, only time will tell. I do however have a dulll pain around the the C5 and T4 areas when I am tired of feel stressed. Nothing two Asprins cannot cope with.

    My Oncologist has reffersd me for a Colonoscopy due to bleeding with Bowel movements. This happens at least once every 10 days. It would most like be Radiation induced Proctitis. I am not at all concerned that it could be something more sisnister, better be safe than sorry. 

    I have updated my profile as there do not appear to be may patients with Mixed DAC plus all the other negative features I have. It just shows that we are all different and we cannot read to much in what Dr Google says.

    All of the best.

    Munster

  • Hi  / what a detailed and, ultimately, reassuring update.  I’ve also re-read your profile. Such information is so valuable to those who follow us. Oh, and you are such a warrior whose positivity shines through.   AW

  • Great Post  

    I can only echo  comments.

    Best wishes - Brian.

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  • I had to travel to Thailand and Bali for 3 months for work

    One point deducted on the sympathy scale - please pass me the world’s tiniest violin LOL Joy    AW

  • Ha Ha,

    I had the most amazing time with my wife. She ensured that it was not all work. We lived life and made time to smell the roses.

    Cheers

  • Hi All

    It looks like I may still have a little problem to deal with. My PSA count has increased from 0.097 ng/dl to 0.3 ng/dl in 3 months.

    I am booked in for another PSMA PET scan on Friday 31 October. Who knows what they find or not find. My Oncologist for the first time showed real concern and did not mention the “Cure” word. His prognosis was concerning. 

    It seems like once you have Intraductal invasion it is a little harder to cure. 

    I look forward to getting this little problem solved and kicked into remission.

    All of the best to everyone.

    Munster

  • Hi  - 0.3 is still a low figure, so not suggestive of rampant cancer. You have had full testosterone back for a couple of years now, so I would hope that this PSA figure is indicative of a small area suitable for targeted SBRT or similar.  Not sure PSMA PET will pick up such a small amount.  However, by the time you get your appointment it may be big enough to detect.  Good luck.  AW

  • Hello  

    Thank you for the update - although I am sorry to read your post. I wish you well with the scan and hope for the best.

    Do keep us updated - we are all with you here.

    Best wishes - Brian.

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    Macmillan Support Line - 0808 808 00 00, 7 days a week between 8am-8pm

    Strength, Courage, Faith, Hope, Defiance, VICTORY.

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  • Hi  so sorry to read about your PSA increase, although small, we have both been here before.  Am I right in thinking you are not on HT at present?  Good luck with your PET scan.

    Best wishes, David

    Please remember that I am not medically trained and the above are my personal views.