PSA results while taking Abiraterone

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My husband (who is Gleason 9) was started on Abiraterone 3 months ago with continued Prostap injections after the Bicalutamide eventually increased his PSA.   At first the PSA reduced rapidly but at his last 2 reviews it's stayed at 0.9.   The oncologist didn't seem worried but we're disappointed that it hasn't continued its former encouraging dive.  A PET scan showed it had spread a little through the prostate and into the lymph nodes and we're worried that it's spreading further all the while the PSA isn't reducing much.  No further scans have been suggested as they're concentrating on treating his other cancer and the PC seems to have taken a back seat at the moment.

  

  • Hi Chocoholic

    Bit puzzled when u talk about other cancer?

    .9 is ok, shows the HT is working, probably couldn't expect it to go to zero.

    Steve 

  • Thanks Steve.  That’s a relief.   Our onco is very busy & doesn’t give us time to query anything.

    The other cancer is adenocarcinoma of the lung, discovered during the PET scan of the prostate but being treated as a separate cancer rather than part of the PC.   He's currently awaiting a lobectomy.

  • Good evening Chocoholic

    The hormone treatment should hold the PC where it is - has the oncologist said what further treatment you are due as hormones alone will only work for a limited number of years. PSA of 0.9 is fine, mine only came down to 1.78 after 9 months of HT (although it was 182!).

    Good Luck with your journey.

    Kind Regards - Brian.

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  • Ok, sorry to hear,  yes obviously the lung cancer more important at this stage.

    The PC seems stable at the moment with the HT 

    Hope things go ok.

    Best wishes

    Steve 

  • Many thanks Steve.  Op scheduled provisionally for next Sunday so hopefully not long to wait.

  • Hi Brian, thanks for your reply.

    His PC returned in a more aggressive form 7 yrs ago after brachytherapy missed some cells.   He was told that the hormone therapies will only work for so long.   Prostap alone worked for 5 yrs, added Bicalutamide for 2, and now Abiraterone has replaced the Bicalutamide.   It’s now a question of waiting to see how that goes before they suggest anything else.

    The oncologist just said there are more options available now but it’s doubtful that radiation is one of them due to the  brachytherapy.   

    I feel a bit embarrassed telling you that 13 has been his highest reading ever but I suppose everyone’s case is different.  His dad’s PSA was over 200 when diagnosed but it was a slow growing tumour and he lasted about 10 years on Zoladex.

    I wish you all the best for your own treatment.   Hazel  

  • Hi Hazel

    It does sound like the oncologist has got the thing in hand. I am a Gleason 9 (original diagnosis 7 but read my profile) and the HT has brought mine down. There are other treatments and more are being developed every year. I would think as Grundo said above sort the lung cancer out first, PC is slow growing an it's under control. Try not to worry too much.

    Best wishes - Brian.

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  • Hi Brian,

    Have just been reading your profile.   My hubby has certainly got off lightly compared to you!   He was lucky in a way as his dad and brother had already had PC so he started having regular PSA tests.   His only symptoms were gradually increasing ED and visits to the loo.   His PSA was 12.5 when he was first referred, Gleason 6. 

    Since being started on hormone therapy when the cancer returned in 2015, he’s had a few flushes, gradually developed manboobs plus losing body hair, and also has more urinary urgency.   Any tiredness he was experiencing was down to sleep apnoea, which was easily resolved with a CPAP machine.  Mind you, at 73 neither of us can party till dawn any longer!

    I’m glad your TURP was successful and you’ve been able to shed the catheter, which itself can cause problems.   I hope that the radiotherapy will cause you the minimum of side effects.

    As you say, there are an increasing number of treatments around now to fight this thing.   

    Best wishes, Hazel

  • Cheers Hazel

    Just completed day 7 of radiotherapy and just starting to feel the effects. as you say at 67 I can't party either.

    Good luck with your journey and keep us posted with your progress.

    Kind regards and Best Wishes - Brian.

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