PSMA

I’m so sorry to hear about your Dad’s situation. His disease appears to be castration resistant now high means hormone therapies no longer work.

I don’t have experience of the Lu-PSMA-617 but know it’s a targeted therapy for PSMA expressing prostate cancer. See summary below. I hope someone who has experience contacts you. Hope also your Dad finds a way forward with treatment.

About ¹⁷⁷Lu-PSMA-617
¹⁷⁷Lu-PSMA-617 is an investigational PSMA-targeted radioligand therapy for metastatic castration-resistant prostate cancer. It is a type of precision cancer treatment combining a targeting compound (ligand) with a therapeutic radioisotope (a radioactive particle)^11-13. After administration into the bloodstream, ¹⁷⁷Lu-PSMA-617 binds to prostate cancer cells that express PSMA¹⁴, a transmembrane protein, with high tumor-to-normal tissue uptake^11,15,16. Once bound, emissions from the radioisotope damage tumor cells, disrupting their ability to replicate and/or triggering cell death^17-19. The radiation from the radioisotope works over very short distances to limit damage to surrounding cells^10,11,15.

Thank you - it’s first time I’ve understood it