Oliparab

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I've been taking oliparab for a while and am struggling with nausea and vomiting a lot.

My consultant has reduced my dose from 600mg to 400mg because of this but I'm now concerned that they won't be so effective at lower dose. Has anyone else had their dose reduced?

  • Hello there - so sorry to hear you're getting nausea & vomiting - I too am on Oliparib and my dose has been reduced to 500mg a day (250 taken at am & 250 taken at pm) as it was really lowering my immune system ( & I'm still on targeted chemotherapy). Ironically having gone through full chemo for stage 4 ovarian, the only time I've considered sickness tablets is with taking the Oliparib! I've since found I get no nausea when I've eaten something - in the morning all I need is a small spoonful of yogurt (for example) then take my morning dose, and for me it really works. By the evening I've usually eaten dinner and have not had nausea then. Even when I don't always feel like eating in the morning the yogurt has always helped me. My thinking is that even on a slightly lower dose my body will respond better, as I understand it, it builds up in the body too? x

  • Hello, really sorry to hear you're having a rough time on Olaparib. I was on the 600mg dose for 2 years and had to take metaclopromide (anti sickness) at the same time. I tended to take one of these first of all and then ate some toast or crackers in between taking the olaparib, it took me around 5 minutes to take the tablets but I struggled to swallow them otherwise. I had to do same again in the evening but it seemed to work without the dose being lowered. Hope you find something that works for you ... I know it's not easy. I also struggled with fatigue but it was definitely worth it as the tablets have been very good in keeping the cancer at bay. Sending you lots of good wishes.