Choice of inhibitors after chemo

Hi and a very warm welcome to the online community

I can't help with your question about inhibitors, as I had a different type of cancer, but I noticed that your post hadn't had any replies yet. Responding to you will 'bump' your post back to the top of the discussion list where it'll be more easily seen.

While you're waiting for replies it would be great if you could pop something about your diagnosis and treatment into your profile as it really helps others when answering or looking for someone with a similar pathway. It also means that you don't have to keep repeating yourself. To do this click on your username and then select 'Profile'. You can amend it at any time and if you're not sure what to write you can take a look at mine by clicking on my username.

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1. Hi Kate56, I have advanced (stage 4b) Ovarian cancer. I started on Olaparib after my chemotherapy but didn't get on very well with it. I felt really exhausted at times and developed pneumopathy which is an extremely rare but potentially serious side effect of Olaparib so had to stop it. I am now on Niraparib which I started in early June and so far I am doing better on it.. I experienced high blood pressure and constipation which are common side effects of Niraparib but both have been easily  controlled by medication. In general I feel better than I felt on Olaparib but still experience some episodes of tiredness. However I,m sure others will get on better with Olaparib than Niraparib, everyone is different.

PARP inhibitors are powerful drugs and I think most people will experience some side effects. However the extent of these is  difficult to predict as they can vary widely between individuals. I chose to  try them because my cancer is  very advanced and I am keen to keep it at bay as long as possible before having  more chemotherapy. 

What stage is your cancer?

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Hi SJB58

many thanks for your response. I have recently been given the all clear but have been advised by the oncology team to take either Olaparib with Navistan or Niraparib for the next three years to help prevent re- occurance. I have gone with Niraparib. I do feel very anxoius about taking these tablets but your message has helped. Thank you.

Hi Kate, 

Fingers crossed you get on Ok with Niraparib, let me know how it goes or if you have any more questions. If the Niraparib doesn't go well then there is always the option to switch to Olaparib.  

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