Unexplained weight gain

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Hi everyone, I've been on immunotherapy Atezolizumab since September 25, every month I noticed another increase in my weight and I wasn't overly worried as I know my weight can yo-yo a bit. At the start of the year I had to have a break from treatment and at that point I was becoming more uncomfortable with the weight gain and just started to pay a little more attention to what I was eating,  (not that it was really bad in the first place) along with steadily increasing my daily walks adding in a few harder hikes. When I restarted treatment 2 months ago my weight had again increased ( I was expecting it to be the same or small loss). Once again it's creeping up every week there isn't really any significant changes I can make with diet or exercise and I'm a little concerned that if it's down to the treatment it's just going to counter out the good it's doing.

Anybody else have any experience?

  • Hello, I  am on pembrolizumab and it has affected my thyroid. I have hypothyroidism, the symptoms of which are dry skin, slow gut motility and weight gain. I have now started on levothyroxine which will be monitored until they find the correct dosage. I don't know if this is what you have and of course the regular blood tests should pick it up anyway as they test your TSH, T3 and T4 but it might be worth checking.