What does P16 negative mean , does it mean I have a high chance of it coming back ?
P16 is a protein that shows up on a special stain. It’s a surrogate marker for HPV. HPV cancers are very sensitive to radiotherapy so it means that it’s curable and less likely to recur.
Aly You should ask your oncologist what bearing your path results have. Head and neck cancer has a high cure rate whatever the cause.
I would just concentrate on getting better and look forward to living a good long life.
Whatever cancer throws your way, we’re right there with you.
We’re here to provide physical, financial and emotional support.
© Macmillan Cancer Support 2026 © Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Also operating in Northern Ireland. A company limited by guarantee, registered in England and Wales company number 2400969. Isle of Man company number 4694F. Registered office: 3rd Floor, Bronze Building, The Forge, 105 Sumner Street, London, SE1 9HZ. VAT no: 668265007