Allergic reaction to chemo

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Well all seemed to be going well. Mid point scan showed where lymph nodes infected they weren't now. Other things seen on lungs shrunk. Everything pointed to treatment working. After all that I've had three allergic reaction, first days after, second hours after, ended up in resus, the last one, lower dose, as soon as I was taken of the drips, temperature spared hives came up, felt really poorly... hospital stay again. Had anyone else had this happen? 

Can they change chemo drugs part way through?