3C1 with 5 lymph nodes involved. I started the INTERLACE protocol with induction chemo on the 7th of October. I had an MRI on 14th November which was the last week of induction chemo. My consultant just told me that the tumor has had a complete response and lymph nodes shrunk with just induction chemo! This is the best case outcome from induction as was initially told stable disease is the expection, partial response maybe possible and complete response is unlikely but the most desirable outcome.
Comsiderations- I know I'm not out of the woods yet and stil CRT is the curative part of treatment which is still going ahead. Chemo induction, which is essentially INTERLACE is meant to target micro metastatic tumors not picked up by scans. They target fast deciding cells and so if there is vascularity in the tumor and it is actively deviding, you've got a good chance of seeing some response. Of course everyone responds differently but given how varied this tumor is, please consider and ask for the INTERLACE protocol - it should be the gold standard if it isn't already.
Hi NoraB67a03b
Thats really great news for you! I hope you’re feeling well and ready for the next stage.
We’ve had some really good discussion in the group recently about the Interlace Trial, and it’s good to read your experience of the induction chemo has been so positive.
I wish you well with the next stage of your treatment-if you’ve got any questions as you go along just ask away. Lots of us have done the concurrent chemo and radio and come through the other side.
Sarah xx
Thank you Sarah! I've started CRT today and feeling the nausea already but ready for the next step for sure.
Yes, definitely, to your point - CRT is the curative part of treatment as induction is meant for micrometastasis. CRT is what directly targets the cancer. Apart from the micrometastasis, there is a chance INTERLACE could also provide an initial blow to the cancer and then CRT for the main treatment. I'm glad there is a discussion around this here in the forum.
I'm sure to have some questions regarding radiotherapy. I found the blog on things you wish you had known before starting radiotherapy very very useful and very grateful for everyone who shared their experience.
Wishing everyone here well whatever the treatment plan and finger crossed for the best outcomes ️
I was given anti sickness meds at the start of my treatment-did you get any given to you yet? I I found it better to take them in anticipation rather than when sickness starts, but didn’t find nausea and/or sickness a real side effect for me going through my treatment. More tiredness, and then other side effects began when I was 3 weeks in.
This is a link to the thread about the Interlace trial in case you haven’t seen it before. Lots of interesting discussion about it.
Sarah xx
Whatever cancer throws your way, we’re right there with you.
We’re here to provide physical, financial and emotional support.
© Macmillan Cancer Support 2025 © Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Also operating in Northern Ireland. A company limited by guarantee, registered in England and Wales company number 2400969. Isle of Man company number 4694F. Registered office: 3rd Floor, Bronze Building, The Forge, 105 Sumner Street, London, SE1 9HZ. VAT no: 668265007