Abemaciclib & liver

Hi, 

I’ve just started my 2nd cycle of Abemaciclib x 2 per day. I was on 150mg for the first month and now I’ve been reduced to 100mg. I was experiencing severe side effects of diarrhoea and nausea which I believe can happen when taking this tablet. I also take Letrozole, Adcal D3 and 4 weekly injections of Zoladex. 

I’ve never had a problem with my bloods in the past 12 months until now, my kidney levels went really low. I had to stop taking it for a week, as I was advised by the oncologist. I believe this was due to dehydration from the side effects. My kidney function is now back to normal and I’ve just started taking the 2nd cycle at 100mg. 

Im hoping that it doesn’t effects my kidneys again and that I don’t experience the same extreme side effects as before.  

 Hope this helps 

xx

Hi 

thank you for your reply . I’m so glad your bloods have returned to normal , the D in particular can be tough ! 
xx

Anyone else ? 
panicking  xx

• Hi Dolly

I was on Abemaciclib for about 6 weeks and my ALT went up to 900 . I came off it and had scans MRI and saw liver specialist. It continued going up to 1900 and then started falling back down to normal after a few months. Nothing showed up on any scans and specialist said it was just a reaction to the pills so hopefully that is all yours is x

Hey 

Wow sounds like your liver was not happy with having those drugs at first ! Glad it’s all settled  

thank you  x

Hi Dollydimple, how was your liver scan. I’ve had my bloods taken today and my GGT is 119. I’m on my 11th cycle of Abemaciclib. I have an appointment on Friday but my ALT and LFT’s  hasn’t come up on patient knows best, I suspect that’s because it’s abnormal. My ALP is also in upper region of normal. I’ve recently had a respiratory infection and required antibiotics so I’m unsure if that has influenced my blood results. Just feeling very anxious and don’t want to spread my anxiety by discussing it with family or friends.