Letrozole making my face fall off!

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I have been on Letrozole for about three months, no unbearable side effects just the usual aches, stiffness, insomnia etc but over the last few weeks the skin on my face has literally started to fall off!

It looks like severe psoriasis (which I have never suffered from), it's sore, itchy and very red.  I haven't changed anything or used anything new only the Letrozole.  I was just beginning to feel me like myself again and now I don't want to go out because it's so bad.  My GP has helpfully offered me a telephone appointment so I'm not sure how much they can do without seeing me Rolling eyes

Has anyone had this side effect and did you find anything to help?  I'm not using anything on my face but water and an unscented moisturiser but it's not improving.  

  • Hi  sorry to hear you’re suffering with your skin. It’s hard enough feeling different, looking different is an extra trouble we can do without.

    I don’t have quite the same but my skin certainly hasn’t benefited from Letrozole. I’ve found a couple of products that have really helped (face and body). 

    Moogoo do a range of creams that are good for sore, sensitive skin. Their sensitive skin balm is great for rough, sore and itchy skin. I think you can get samples to try. 

    Hope you find something that works for you x

  • Hello Gee65, sounds rubbish... Excuse my ignorance - I don't know what Letrozole is but I'm on wk5 of 12 weekly Paclitaxol chemo atm... And my face, neck, chest, behind ears all exploded on wk2 - disgusting sore measles type raised rash and covered in pimples which then grew worryingly... Chemo hotline said it was allergic reaction so double dosed piriton to see if it helped - which it did quite a bit but when I went back for next chemo and mentioned the (by then, much reduced) rash, the lovely nurse handed me magic cream immediately - Pliazon Plus. It's 'regenerative, normalising moisturising cream' aimed at cancer patients and has really been amazing at reducing the roughness and discolouration etc and getting my face feeling smooth and more normal again. I didn't know what it was and stupidly just said thank you, without asking so found it on Amazon later & read the info there. Would thoroughly recommend but is about £30 or £40 for tube so might be worth asking for on prescription? I do hope you find some help and relief very soon. Sending love and strength to get yourself through this cloud to the sunshine on the other side. X

  • I take exemestane rather than letrozole but I do have psoriasis-like rashes on various parts of my body, mainly ankles, hips and wrists. I was given steroid cream to use, which takes a while to work and I've had to use it twice a day or it doesn't make much difference.

    I spoke to my BCN about it but she didn't think it would be the aromatase inhibiter and suggested coming off exemestane for 6 weeks to see if it cleared. I haven't done that as I don't want to interrupt my treatment plan, plus whenever I look up side effects of exemestane, rashes are well known.

    Hopefully you can get a cream for it to calm it down.

  • It sounds like you must be allergic to something in it. My brother and his daughter have psoriasis. He is asthmatic as well. They may change the way we respond to foods maybe. I've just changed to Tamoxifen after 3 mths on Letrozole. There are a few foods and things I need to avoid now. It changes the body dramatically, it seems logical to me what you are saying. 

    I had a SL run in with the Professor if Oncology at my local unit. He said I haven't got osteoporosis, he said the people doing dexa scans only  want to keep people going back. Thankfully the person I was seeing didn't agree with him. I'm still wondering what I should do about his attitude. Xxxxx