Neuropathy associated with Tamoxifen

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I wonder if there is anyone out there who is also experiencing severe numbness and chronic pain in their feet and legs after taking Tamoxifen.

I didn't have chemotherapy (only 4 weeks radiotherapy) for my stage II breast cancer (invasive ductal carcinoma) and started taking Tamoxifen 6 weeks ago. The first months supply of Tamoxifen was a different brand but the same dose.

About 10 days ago I started to experience numbness on the soles of my feet. This has worsened and extended up my legs.

I am now in so much pain I can't sleep and can barely walk. There is no swelling to my feet or legs and the pain is worse on the top of my feet and all the way up to my knees (but I also have pain on the soles of my feet. I am of normal weight and I exercise three times a week although this has been limited over the last 10 days due to the pain. I am 50 years old and was previously on a high dose HRT before my diagnosis in February this year. My feet are cold to the touch even after exercise. I have great difficulty moving my feet or wiggling my toes.

I am taking no other medication other than Tamoxifen (which my locum GP advised me to stop taking immediately).

Would love to hear from anyone who can give me some advice on what to do next.

Thanks so much in advance

Helena

MabelLean 8 months ago

'I wonder if there is anyone out there who is also experiencing severe numbness and chronic pain in their feet and legs after taking Tamoxifen..."

Yes! Day 15 on it and getting these symptoms as you have already.

I tried Letrozole for 1 1/2 months and was very drug sensitive to it and had to stop because of side effects.

Letrozole Aromatase Hormone Inhibitor was far too detrimental to my cardiopulmonary limitations amongst other extremely harsh side effects.

1. Extreme exhaustion

2. A-fibrillation

3 Nausea

4. Muscular-joint pain

5. Higher lipid count

6. Raised out of controlled range Blood Glucose A-1C levels previously balanced

7. Extremely wide ranging high to low BP swings. Diastolic plunged many times to under 50 causing dizziness just shy of unconsciousness

8. Angina frequency increased to daily and grew more intense in pain

9. BUN and Creatinine Levels now ranging high off normal.

Now trying Taxoxifen but this will not work out either apparently. Only on a 30 Day Trial.

Stopping tonight at Day 15.

MabelLean 8 months ago in reply to MabelLean

~ Mabellean

Surgery 1/12;/2024; 1/26/2024 DX 1/2024, Right, Intrusive Ductal and Lobular Carcinoma, Stage IA, Grade 2, ER+, PR+, HER2+, ISH

Treatment → * NEED: MRI Bi-annually along with 3D Mammography and Sonogram

June 1, MRI Results → * NO cancer reoccurrence

~ 1 Corinthians 16:13 Final Exhortations Watch, stand fast in the faith, be brave, be strong.

DurkTheDutchman 1 month ago

Same here, I took it only about 6 moths( in 2009 double mastectomy ) and threw it in the garbage as I didn't feel good taking it and to top it off I read the small print, NOT GOOD. As far as the numb feeling under my feet I first thought was because I did a lot of walking and standing, however now (2024) I finally realized it had to do with the Tamoxifen. My feet are hot especially at night and tingling and I have it slightly in my fingers as well. I am not in pain thankfully but it is bloody annoying I feel bad for people who were scared into taking this garbage for more than 5 years and finished up with worse problems. I am a 83 years "young" male.

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Neuropathy associated with Tamoxifen