Lonsurf and Avastin

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Hello there, I am on my 8th cycle of Lonsurf with Avastin and the fatigue is really affecting me, does anyone have any experience of improvement with dose reduction or whether the fatigue stabilises with continued use or is it likely to get worse?  When I am in the middle of my cycle I just feel like I don’t want to carry on with the treatment because I feel so awful. 
Thank you all x