Terrible sickness after Folfox chemo

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My husband had his first Folfox chemo cycle on Wednesday and felt fine Thursday. This morning at 5am was nauseous and vomited was also dizzy, headache and feeling weak and very tired. Couldn’t eat or drink as couldn’t keep anything down.

vomited again 6 times and has a migraine.

Hes been on the below drugs since he came home from chemo Wednesday.

Dexamethasone

Ondansetron

Metoclopromide

Has anyone else still had terrible nausea and vomiting even on the anti sickness drugs?