BCG affecting the prostate - Granulomatous

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Hi Everyone

Has anyone heard of or have any knowledge or experience with a potential side effect of BCG treatment known as Granulomatous affecting the prostate?

I’m 15 months post-diagnosis T1aG3 CIS and I recently had a routine biopsy in November, which thankfully came back clear. However, my consultant raised concerns about my enlarged prostate and an MRI scan in December revealed two abnormalities, graded 4 and 5, which could potentially be cancer. I had a biopsy on my prostate this week, and now it’s the long, stressful wait for the results. My recent PSA result was 2.5, which is within normal range.

As you can imagine, it’s a very tough time facing the possibility of prostate cancer in addition to my high-grade bladder cancer. I’ve read and researched as much as I can about potential side effects of BCG on the prostate, and two of my doctors have suggested that Granulomatous scarring can cause the prostate to become firm and bulky, sometimes presenting as cancer when it’s actually benign.

I know it’s a bit of a long shot asking this question, but under the circumstances, I thought I’d give it a try.

Thanks

  • Hello Frank, sorry to hear your news. I’m afraid I can’t help you. No doubt someone on this forum will be able to share their experiences. Stay well. Garviv

  • Not prostate related, but I had a long-troublesome molar extracted by the head of a high-end private practice recently. He explained that he had removed little balls from the bottom of the socket as well as the other things he had done to ensure [successfully] best healing. I asked what the little balls were, and he explained they were granulomas, which is where the body attempts to deal with the infection, but because they swell, this causes all the pressure that accounts for the pain. Presumably because the BCG is a form of challenge to the immune system, it can sometimes provoke a similar reaction in the prostate. Mr D has just had a TURBT on a 'thickened area of the anterior wall of his bladder' which fortunately was chronic inflammation not cancerous. However I wonder if this may have been a similar effect from the BCG he had five or six years ago. In any case it clears the way for surgery on his decidedly enlarged prostate. The hope is to reduce up-in-the-night nuisance.

    I hope you get good answers soon, 

    Denby

  • Again sorry I can't really help with your questions and sorry to hear you noe have this potentially on top of the bladder cancer. Fingers crossed it's something else or benign for you and you can focus on fighting the one lot. 

    I am sure someone will be along who can give you better advice, and as always the waiting is the hardest bit not knowing what your dealing with. 

    I wish you the best of luck and the most positive outcome with the biopsy hopefully. 

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  •   Hi , I had problems with my BCG, which caused a lot of pain in my prostate. I elected to give up BCG after 9 installations, as the pain in the bladder and prostate had become too much. The pre op assessment included an MRI, which suggested an intermediate score and possibility at least of cancer cells developing. Never mind, the prostate was removed in the RC. No cancer cells were found in the post op histology. But the prostate was quite inflamed from the BCG. Granuloma was found outside the bladder sure to a hole in the bladder wall from surgery, and BCG getting into my abdominal cavity. My PSA pre op was very low.

    I don’t know if this helps. Best to try and stay calm and wait for biopsy results, it may turn out to be bad inflammation, a known side effect of BCG treatment, unfortunately.

    all the best, Leo