Folfox Treatment and Symptoms

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Hi everyone. I am a carer for my wife and she has started Folfox treatment for her Stage 4 diagnosis. She has had cholangiocarcinoma for 5 years so we have gone through numerous treatments. Has anyone else been through this treatment and had a symptom of severe pain? This I think at the moment is the worse symptom and we are trying to navigate our way through it and how best to calm her down. It's stressful for her. Any advice would be greatly appreciated.