I am currently 10 month post SCT. I had a DLI in July as my T cells were low. I encountered no GVHD with either
I have recently had my third routine bone marrow biopsy & was told that my cells are not where they should be (as at month 2 biopsy ) & still on the low side. So I’m hoping that my month 3 results will increase dramatically.
I have been told to prepare myself just incase I need a second DLI & that the chances of GVHD are higher with the second DLI.
I just wanted to know if other people have experienced this & how they have recovered.
I am feeling very deflated atm as I had hoped the first dli would sort my chimerisms out and I could get back to normality.
Hi again Annie Annie_19, this is the 'nervey time' and it's all about holding your nerve. This is taken from my treatment timeline.
Following my first Allo SCT -
BMB at day +100 showed Mixed Chimerism 55%
Day +160 DLI (No GvHD)
Day +192 (Christmas Eve) I was told my graft had failed.
I went back 10 months later and had my second Allo SCT......
Days + 85 to + 157 skin GvHD so Cyclosporin was continued and slowly reduced
Day + 100 BMB showed Mixed Chimerism 69%
Day + 114 DLI (No1)
Day + 196 Cyclosporin stopped
Day + 269 BMB showed Mixed Chimerism 48%
Day + 281 DLI (No2)
Day + 284 GvHD in bone marrow - weekly blood transfusions for three months
Day + 325 BMB showed Mixed Chimerism 65%
Day + 304 DLI (No 3)
Day + 332….. Classed as in remission and NED (No Evident Disease)......... which I found bizarre as a Chimerism Blood Test still showed Mixed Chimerism but in their eyes my Mixed Chimerism was steady - Some people never reach 100% Donour
Day + 455 BMB showed Mixed Chimerism 70%
Day + 697 BMB Showed Whole Blood Lymphoid and Myeloid Lineages are 100% Donor........ 23 months after my second Allo SCT
((hugs))
